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Titolo:
Analysis of T cell receptor V-beta gene usage during the course of diseasein patients with chronic hepatitis B
Autore:
Dou, HY; Wu, JC; Peng, WL; Chang, CM; Chi, WK; Chu, YD; Hu, CP;
Indirizzi:
Vet Gen Hosp, Dept Med Res, Taipei 112, Taiwan Vet Gen Hosp Taipei Taiwan 112 en Hosp, Dept Med Res, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 biol & Immunol, Taipei 112, Taiwan Vet Gen Hosp, Dept Med, Taipei, Taiwan Vet Gen Hosp Taipei TaiwanVet Gen Hosp, Dept Med, Taipei, Taiwan Natl Hlth Res Inst, Taipei, Taiwan Natl Hlth Res Inst Taipei TaiwanNatl Hlth Res Inst, Taipei, Taiwan Dev Ctr Biotechnol, Proc Dev Div, Taipei, Taiwan Dev Ctr Biotechnol Taipei Taiwan otechnol, Proc Dev Div, Taipei, Taiwan
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 6, volume: 5, anno: 1998,
pagine: 428 - 434
SICI:
1021-7770(199811/12)5:6<428:AOTCRV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; SURFACE-ANTIGEN; VIRUS; CLONES; CORE; EXACERBATIONS; INFECTION;
Keywords:
T cell receptor; V-beta gene usage; immune response; chronic HBV infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, CP Vet Gen Hosp, Dept Med Res, Taipei 112, Taiwan Vet Gen Hosp Taipei Taiwan 112 , Dept Med Res, Taipei 112, Taiwan
Citazione:
H.Y. Dou et al., "Analysis of T cell receptor V-beta gene usage during the course of diseasein patients with chronic hepatitis B", J BIOMED SC, 5(6), 1998, pp. 428-434

Abstract

The T cell receptor (TCR) is a heterodimeric molecule expressed on the surface of T cells and recognizes foreign peptides presented by the major histocompatibility complex on the surface of antigen-presenting cells or virus-infected cells. Analysis of TCR usage by T cells which recognize hepatitis B virus (HBV) provides further insight into the participation of T cell populations during the course of disease, In this study, we examined the T-cell-proliferative response and the TCR V beta gene usage of peripheral blood mononuclear cells in 3 patients with clinical evidence typical of chronic hepatitis B. All 3 patients had significant T-cell proliferative responses against HBV core antigen (HBcAg) during the remission stage, while no responses were detected during the acute exacerbation stage. In addition, the TCRV-beta 7 gene was utilized more frequently in T cells recognizing HBcAg during remission, while TCR V-beta 1 and V-beta 2 were utilized at a higher percentage during acute exacerbation. On the contrary, the T cell proliferative response against HBV surface antigen was undetectable and no specific Vbeta gene was utilized more frequently by all 3 patients, regardless of disease state. Our longitudinal studies, although based on a small sample of patients, demonstrate that the population of HBcAg-activated T cells altersduring the course of disease in chronic hepatitis B patients.

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Documento generato il 11/07/20 alle ore 20:57:55