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Titolo:
Bcl-2 prevents caspase-independent cell death
Autore:
Okuno, S; Shimizu, S; Ito, T; Nomura, M; Hamada, E; Tsujimoto, Y; Matsuda, H;
Indirizzi:
Osaka Univ, Sch Med, Biomed Res Ctr, Dept Surg 1, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 es Ctr, Dept Surg 1, Osaka 5650871, Japan Osaka Univ, Sch Med, Biomed Res Ctr, Dept Med Genet, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 Ctr, Dept Med Genet, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 51, volume: 273, anno: 1998,
pagine: 34272 - 34277
SICI:
0021-9258(199812)273:51<34272:BPCCD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CYTOCHROME-C; MEDIATED APOPTOSIS; PROTEASES; INHIBITION; PROTEIN; RELEASE; MITOCHONDRIA; EXPRESSION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Shimizu, S Osaka871,v, Sch Med, Biomed Res Ctr, Dept Surg 1, 2-2 Yamadaoka, Osaka 5650 Osaka Univ 2-2 Yamadaoka Osaka Japan 5650871 daoka, Osaka 5650
Citazione:
S. Okuno et al., "Bcl-2 prevents caspase-independent cell death", J BIOL CHEM, 273(51), 1998, pp. 34272-34277

Abstract

Nitric oxide (NO) is implicated in apoptosis and has both cytotoxic and cytoprotective effects. Exogenous NO induced the death of PC12 and HeLa cellsvia a process showing features of both apoptosis: and necrosis, with chromatin condensation, nuclear compaction, and mitochondrial swelling. Activation of caspases was not observed during NO-induced cell death. In addition, cell death was not inhibited by peptide caspase inhibitors or by expressionof p35, a baculovirus-encoded caspase inhibitor, indicating that NO-induced cell death was independent of caspases. NO-induced cell death was enhanced by Bar expression in a caspase-independent manner and prevented by the anti-cell death protein Bcl-2. Although Bcl-2 has previously been shown to prevent cell. death by inhibiting caspase activation, these results indicate that it can also prevent cell death via a caspase-independent mechanism.

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Documento generato il 03/04/20 alle ore 08:03:51