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Titolo:
Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle
Autore:
Egginton, S; Hudlicka, O; Brown, MD; Walter, H; Weiss, JB; Bate, A;
Indirizzi:
Univ5Birmingham, Sch Med, Dept Physiol, Angiogenesis Res Grp, Birmingham B1 Univ Birmingham Birmingham W Midlands England B15 2TT Grp, Birmingham B1 UnivEnglandgham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands,Univ Birmingham Birmingham W Midlands England B15 2TT 15 2TT, W Midlands, Hope,Hosp, Dept Rheumatol, Wolfson Angiogenesis Unit, Salford M6 2JR, Lancs Hope Hosp Salford Lancs England M6 2JR enesis Unit, Salford M6 2JR, Lancs
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 85, anno: 1998,
pagine: 2025 - 2032
SICI:
8750-7587(199812)85:6<2025:CGIRTB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING ANGIOGENIC FACTOR; EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS; FIBER TYPES; PLANTARIS; STRETCH; HYPERTROPHY; EXERCISE;
Keywords:
synergist extirpation; angiogenesis; growth factors; blood flow; microspheres; fatigue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Egginton, S Univ5Birmingham, Sch Med, Dept Physiol, Angiogenesis Res Grp, Birmingham B1 Univ Birmingham Birmingham W Midlands England B15 2TT gham B1
Citazione:
S. Egginton et al., "Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle", J APP PHYSL, 85(6), 1998, pp. 2025-2032

Abstract

Rat extensor digitorum longus muscles were overloaded by stretch after removal of the synergist tibialis anterior muscle to determine the relationship between capillary growth, muscle blood flow, and presence of growth factors. After 2 wk, sarcomere length increased from 2.4 to 2.9 mu m. Capillary-to-fiber ratio, estimated from alkaline phosphatase-stained frozen sections, was increased by 33% (P < 0.0001) and 60% (P < 0.01), compared with control muscles (1.44 +/- 0.06) after 2 and 8 wk, respectively. At 2 wk, the increased capillary-to-fiber ratio was not associated with any changes in mRNAfor basic fibroblast growth factor (FGF-2) or its protein distribution. FGF-2 immunoreactivity was present in nerves and large blood vessels but was negative in capillaries, whereas the activity of low-molecular endothelial-cell-stimulating angiogenic factor (ESAF) was 50% higher in stretched muscles. Muscle blood flows measured by radiolabeled microspheres during contractions were not significantly different after 2 or 8 wk(132 +/- 37 and 177 +/- 22 ml.min(-1).100 g(.-1), respectively) from weight-matched controls (156 +/- 12 and 150 +/- 10 ml.min(-1).100 g(.-l), respectively). Resistance tofatigue during 5-min isometric contractions (final/peak tension x 100) wassimilar in 2-wk overloaded and contralateral muscles (85 vs. 80%) and enhanced after 8 wk to 92%, compared with 77% in contralateral muscles and 67% in controls. We conclude that increased blood flow cannot be responsible for initiating expansion of the capillary bed, nor does it explain the reduced fatigue within overloaded muscles. However, stretch can present a mechanical stimulus to capillary growth, acting either directly on the capillary abluminal surface or by upregulating ESAF, but not FGF-2, in the extracellular matrix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:58:04