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Titolo:
EVALUATION OF THE TRANSEPIDERMAL PERMEATION OF DIETHYLENE GLYCOL MONOETHYL ETHER AND SKIN WATER-LOSS
Autore:
GANEMQUINTANAR A; LAFFORGUE C; FALSONRIEG F; BURI P;
Indirizzi:
INTERUNIV CTR GENEVA LYON,PHARMAPEPTIDES F-74166 ARCHAMPS FRANCE INTERUNIV CTR GENEVA LYON,PHARMAPEPTIDES F-74166 ARCHAMPS FRANCE UNIV LYON 1,ISBP F-69373 LYON FRANCE UNIV GENEVA,SCH PHARM CH-1211 GENEVA SWITZERLAND
Titolo Testata:
International journal of pharmaceutics
fascicolo: 2, volume: 147, anno: 1997,
pagine: 165 - 171
SICI:
0378-5173(1997)147:2<165:EOTTPO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERCUTANEOUS-ABSORPTION; ENHANCEMENT; PENETRATION; BARRIER; INVITRO; VEHICLE;
Keywords:
SKIN ABSORPTION; PENETRATION ENHANCER; EPIDERMAL WATER LOSS; DIETHYLENE GLYCOL MONOETHYL ETHER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Ganemquintanar et al., "EVALUATION OF THE TRANSEPIDERMAL PERMEATION OF DIETHYLENE GLYCOL MONOETHYL ETHER AND SKIN WATER-LOSS", International journal of pharmaceutics, 147(2), 1997, pp. 165-171

Abstract

The rate of Transcutol(R) (TC)-water interchange, was studied using whole and stripped hairless rat skin in a modified vertical Franz diffusion cell. The presence of stratum corneum limited the passage of the two solvents, but after stripping of the skin, the rate of TC transferincreased and the water flow rose until the vapour pressure at the skin surface and in the ambient air was similar. The results suggest that TC increased the donor hydration by increasing the outflow of water,with a change in the donor composition. These two opposite fluxes andthe alteration of the bulk constitution of the skin and of the donor compartment throughout the experiment, are important factors to be considered for the permeation studies with this solvent. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:38:44