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Titolo:
CARBOPLATIN LIPOSOMES COATED WITH O-PALMITOYLPULLULAN - IN-VITRO CHARACTERIZATION
Autore:
MOREIRA JN; ALMEIDA LM; GERALDES CF; MADEIRA VMC; COSTA ML;
Indirizzi:
UNIV COIMBRA,FAC FARM,LAB BIOQUIM,RUA COURACA APOSTOLOS P-3000 COIMBRA PORTUGAL UNIV COIMBRA,FAC FARM,LAB TECNOL FARMACEUT P-3000 COIMBRA PORTUGAL UNIV COIMBRA,FCTUC,DEPT BIOQUIM P-3000 COIMBRA PORTUGAL UNIV COIMBRA,CTR NEUROCIENCIAS P-3000 COIMBRA PORTUGAL
Titolo Testata:
International journal of pharmaceutics
fascicolo: 2, volume: 147, anno: 1997,
pagine: 153 - 164
SICI:
0378-5173(1997)147:2<153:CLCWO->2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILAMELLAR LIPOSOMES; ANTICANCER DRUG; STABILITY; CISPLATIN; CANCER; CIS-DIAMMINEDICHLOROPLATINUM(II); MEMBRANES; CAPACITY; INVITRO; BINDING;
Keywords:
CARBOPLATIN; LIPOSOMES; O-PALMITOYLPULLULAN; DRUG-CARRIER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.N. Moreira et al., "CARBOPLATIN LIPOSOMES COATED WITH O-PALMITOYLPULLULAN - IN-VITRO CHARACTERIZATION", International journal of pharmaceutics, 147(2), 1997, pp. 153-164

Abstract

Encapsulation and stability of carboplafin in large unilamellar liposomes (LW) of L-alpha egg phosphatidylcholine (PC), uncoated and coatedwith 0-palmitoylpullulan (OPP), were studied. Synthesized OPP was characterized by infrared (IR) spectroscopy, revealing the existence of acovalent bond between the pullulan and palmitoyl groups, and by proton nuclear magnetic resonance (H-1-NMR) spectroscopy, allowing the calculation of the substitution degree of palmitoyl groups in pullulan (0.4%). Moreover, encapsulated carboplatin does not change the fluorescence polarization of either 1,6-diphenyl-1,3,5-hexatriene (DPH) or 3-[p-(6-phenyl-1,3,5-hexalrienyl]phenylp acid (DPH-PA), suggesting that this drug does not modify the membrane lipid organization either in the bilayer core or in the outer domains, as monitored by DPH and by DPH-PA, respectively. Carboplatin encapsulation in LW and their stability seem to be simultaneously improved by hydration in a medium without chloride ions and with an ionic strength equivalent to 0.6% NaCl. Additionally, it is shown that stability of carboplatin liposomes, as measuredby the platinum remaining associated with liposomes (platinum latency), is improved by coating with OPP, for an OPP/PC weight ratio of 3. Higher OPP/PC weight ratio values (e.g. 7.5) induce an opposite effect. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:54:40