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Titolo:
Mycoplasma infection can sensitize host cells to apoptosis through contribution of apoptotic-like endonuclease(s)
Autore:
Sokolova, IA; Vaughan, ATM; Khodarev, NN;
Indirizzi:
Loyola Univ, Med Ctr, Dept Radiotherapy, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Dept Radiotherapy, Maywood, IL 60153 USA Vysis Inc, Downers Grove, IL USA Vysis Inc Downers Grove IL USAVysis Inc, Downers Grove, IL USA
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 6, volume: 76, anno: 1998,
pagine: 526 - 534
SICI:
0818-9641(199812)76:6<526:MICSHC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTES; MACROPHAGES; PULMONIS; PROTEINS; ENZYME; DEATH; PCR;
Keywords:
apoptosis; endonuclease; Mycoplasma; serine proteases; two-dimensional protein gel electrophoresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Khodarev, NN Univago,cago, Dept Radiat Cellular Oncol, 5798 S Maryland Ave,MC 1106, Chic Univ Chicago 5798 S Maryland Ave,MC 1106 Chicago IL USA 60637
Citazione:
I.A. Sokolova et al., "Mycoplasma infection can sensitize host cells to apoptosis through contribution of apoptotic-like endonuclease(s)", IMM CELL B, 76(6), 1998, pp. 526-534

Abstract

Mycoplasma infection may lead to various pathologies in a broad range of hosts. It has been shown that Mycoplasma may trigger cell death in cell cultures; however, the mechanism remains unknown. In the present paper we show that Mycoplasma infection of different lymphocyte and epithelial tumour cell lines leads to the inhibition of proliferation, and increased cell death,accompanied by DNA fragmentation and the morphological features of apoptosis. We also showed that this infection leads to an increased sensitivity ofcells to various inducers of apoptosis targeting different signalling pathways. Finally, we show that increased apoptosis is associated with overexpression of an endonuclease produced by Mycoplasma. This endonuclease is recovered in the nuclear fraction of host cells, introduces mostly DSB and is active at neutral pH in the presence of divalent cations. Activation of thisendonuclease is connected with limited proteolysis, which may be reproduced in vitro by snake venom serine proteinase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:46:44