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Titolo:
Maternal scleroderma: Placental findings and perinatal outcome
Autore:
Doss, BJ; Jacques, SM; Mayes, MD; Qureshi, F;
Indirizzi:
Hutzel Hosp, Detroit Med Ctr, Dept Pathol, Detroit, MI 48201 USA Hutzel Hosp Detroit MI USA 48201 Ctr, Dept Pathol, Detroit, MI 48201 USA Hutzel Hosp, Detroit Med Ctr, Dept Internal Med, Detroit, MI 48201 USA Hutzel Hosp Detroit MI USA 48201 Dept Internal Med, Detroit, MI 48201 USA Hutzel Hosp, Detroit Med Ctr, Scleroderma Registry, Detroit, MI 48201 USA Hutzel Hosp Detroit MI USA 48201 eroderma Registry, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Detroit, MI USA Wayne State Univ Detroit MI USA yne State Univ, Sch Med, Detroit, MI USA
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 12, volume: 29, anno: 1998,
pagine: 1524 - 1530
SICI:
0046-8177(199812)29:12<1524:MSPFAP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-SCLEROSIS; ACUTE ATHEROSIS; PREGNANCY; PREECLAMPSIA; DISEASE; CELLS; IMMUNOHISTOCHEMISTRY; SUBPOPULATIONS; PATHOLOGY; DECIDUA;
Keywords:
scleroderma; systemic sclerosis; placenta; perinatal outcome; pregnancy; decidual vasculopathy; atherosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Doss, BJ Univ37hicago, Lab Surg Pathol, MC 6101,5841 S Maryland Ave, Chicago, IL 606 Univ Chicago MC 6101,5841 S Maryland Ave Chicago IL USA 60637 606
Citazione:
B.J. Doss et al., "Maternal scleroderma: Placental findings and perinatal outcome", HUMAN PATH, 29(12), 1998, pp. 1524-1530

Abstract

Pregnancy after the onset of scleroderma is uncommon; therefore, placentalfindings and perinatal outcome have rarely been correlated. The histopathologic features of placentas from 13 pregnancies in eight women with scleroderma were recorded and correlated with the clinical features of the mother and fetus. Adverse perinatal outcome included intrauterine fetal demise in five, and previable or preterm delivery in four. A decidual vasculopathy was seen in 5 of the 13 placentas, four of which were associated with intrauterine fetal demise. Decidual blood vessels in the scleroderma patients wereevaluated immunohistochemically for platelet-derived growth factor (PDGF),transforming growth factor beta 1 (TGF-beta 1), T-helper and T-suppressor lymphocytes, macrophages, immunoglobulin (Ig) M, and IgG, and compared withthose from hypertensive and uncomplicated third-trimester pregnancies. Theatherotic blood vessels in scleroderma were characterized by mural macrophages and IgM and IgG deposition and were similar to those seen in placentasfrom hypertensive pregnancies. CD8-positive T cells predominated in normaland hypertensive decidua compared with scleroderma, in which CD4-positive T cells were more frequent. No difference in PDGF or TGF-beta 1 staining was found between scleroderma and control groups. In conclusion, decidual vasculopathy is common in scleroderma, is similar to that seen in hypertension, and is associated with poor perinatal outcome. A trend toward a reversed ratio of decidual CD4- to CD8-positive T cells is seen in scleroderma compared with hypertension and uncomplicated pregnancies. PDGF and TGF-beta 1 donot appear to be involved in the pathogenesis of decidual vasculopathy in scleroderma. HUM PATHOL 28:1524-1530. Copyright (C) 1998 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:23:44