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Titolo:
Animal experimental implantation of an atrial septal defect occluder system
Autore:
Thomsen, AB; Schneider, M; Baandrup, U; Stenberg, EV; Hasenkam, JM; Bagger, JP; Hausdorf, G;
Indirizzi:
AarhusClinv Hosp, Skejby Sygehus, Dept Cardiothorac & Vasc Surg, Inst ExptAarhus Univ Hosp Aarhus Denmark ept Cardiothorac & Vasc Surg, Inst Expt Aarhus Univ Hosp, Skejby Sygehus, Dept Cardiol, Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark Sygehus, Dept Cardiol, Aarhus, Denmark Humboldt Univ, Charite Hosp, Dept Pediat Cardiol, Berlin, Germany HumboldtUniv Berlin Germany Hosp, Dept Pediat Cardiol, Berlin, Germany
Titolo Testata:
HEART
fascicolo: 6, volume: 80, anno: 1998,
pagine: 606 - 611
SICI:
1355-6037(199812)80:6<606:AEIOAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCATHETER CLOSURE; BUTTONED DEVICE; OCCLUSION; EXPERIENCE;
Keywords:
congenital heart disease; atrial septal defect; catheter technique; occluder device;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Thomsen, AB SkejbykSygehus, Dept Res Cardiothorac & Vasc Surg, DK-8200 Aarhus N, Denmar Skejby Sygehus Aarhus Denmark N rg, DK-8200 Aarhus N, Denmar
Citazione:
A.B. Thomsen et al., "Animal experimental implantation of an atrial septal defect occluder system", HEART, 80(6), 1998, pp. 606-611

Abstract

Objective-To establish the implantation technique for the atrial septal defect occluder system (ASDOS) device in an experimental animal model and to determine long term mechanical stability of the device and its in vivo properties in terms of biocompatibility and tissue reaction. Materials and methods-An atrial septal defect was created and the device implanted in 17 pigs (mean weight 30 kg). The implantation technique was refined and modified because of initial technical and anatomical complicationsduring nine acute pilot studies. The technique proved to be feasible in eight subsequent survival studies. Four pigs were electively killed three months after implantation (group 1). The remaining four pigs were killed six months after implantation (group 2). Results-Necropsy showed all devices were embedded in soft tissue three months after implantation. Microscopic examination of atrial septal tissue showed an acute granulomatous inflammatory reaction in group 1 and fibrosis ingroup 2. The intensity of the inflammatory reaction around the device was clearly milder in group 2, indicating a decline in the inflammatory response with time. Clinical and biochemical investigations indicated acceptable biocompatibility of the device. Conclusion-The implantation technique for the ASDOS device in a chronic pig model has been established. Biocompatibility of the device was acceptable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:27:23