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Titolo:
The effect of mannitol upon cochlear dysfunction induced by transient local anoxia
Autore:
Tabuchi, K; Ito, Z; Wada, T; Hara, A; Kusakari, J;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Otolaryngol, Tsukuba, Ibaraki 305, JapanUniv Tsukuba Tsukuba Ibaraki Japan 305 yngol, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 126, anno: 1998,
pagine: 28 - 36
SICI:
0378-5955(199812)126:1-2<28:TEOMUC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR CEREBELLAR ARTERY; LASER-DOPPLER MEASUREMENTS; ACUTE-RENAL-FAILURE; BLOOD-FLOW; LIPID-PEROXIDATION; CEREBRAL-ISCHEMIA; GERBIL COCHLEA; TISSUE-INJURY; FREE-RADICALS; GUINEA-PIG;
Keywords:
cochlea; compound action potential; blood circulation; local anoxia; mannitol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Kusakari, J Univrakikuba, Inst Clin Med, Dept Otolaryngol, 1-1-1 Tennodai,Tsukuba, Iba Univ Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan 305 uba, Iba
Citazione:
K. Tabuchi et al., "The effect of mannitol upon cochlear dysfunction induced by transient local anoxia", HEARING RES, 126(1-2), 1998, pp. 28-36

Abstract

Transient local anoxia of the cochlea was induced by pressing the labyrinthine artery, and compound action potential (CAP) or endocochlear potential (EP) was measured before and after transient local anoxia ranging from 5 to60 min using 106 albino guinea pigs. The complete interruption of the cochlear blood flow by this procedure and its full restoration after releasing the pressure on the artery was confirmed by a laser-Doppler flowmeter. The anoxia of less than 10 min induced no post-anoxic cochlear dysfunction, whereas the anoxia of a longer duration induced an irreversible dysfunction ofthe cochlea. it was evident that the post-anoxic recovery of the CAP threshold was worse as the anoxia period was prolonged, and CAP was almost completely abolished after 60-min anoxia. In animals which were administered mannitol intravenously just after the restoration of the cochlear blood circulation, the recovery of the CAP threshold was significantly better than thatin the control animals, when the animals were subjected to local anoxia of15- to 30-min duration. No beneficial effect, however, was observed in the60-min anoxia group. In conclusion, local anoxia of 10 min or longer caused cochlear dysfunction, which was partially but significantly alleviated bymannitol. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:40:01