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Titolo:
Increased F-2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo
Autore:
Pratico, D; Lee, VMY; Trojanowski, JQ; Rokach, J; Fitzgerald, GA;
Indirizzi:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Therapeut, Philadelphia, PA 19104 USA Univia,nn, Sch Med, Ctr Neurodegenerat Dis Res Pathol & Lab Med, Philadelph Univ Penn Philadelphia PA USA 19104 Dis Res Pathol & Lab Med, Philadelph Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA Florida Inst Technol Melbourne FL USA 32901 Inst, Melbourne, FL 32901 USA Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA Florida Inst Technol Melbourne FL USA 32901 Chem, Melbourne, FL 32901 USA
Titolo Testata:
FASEB JOURNAL
fascicolo: 15, volume: 12, anno: 1998,
pagine: 1777 - 1783
SICI:
0892-6638(199812)12:15<1777:IFIADE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-AMYLOID PEPTIDES; STRESS IN-VIVO; OXIDATIVE DAMAGE; OXIDANT STRESS; BRAIN; PATHOGENESIS; GENERATION; PROTEINS; NEURONS; CORTEX;
Keywords:
oxidative stress; schizophrenia; temporal lobes; neurofibrillary tangles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Fitzgerald, GA 153 Johnson Pavil,3600 Hamilton Walk, Philadelphia, PA 19104 USA 153 Johnson Pavil,3600 Hamilton Walk Philadelphia PA USA 19104
Citazione:
D. Pratico et al., "Increased F-2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo", FASEB J, 12(15), 1998, pp. 1777-1783

Abstract

Alzheimer's disease (AD) includes a group of dementing neurodegenerative disorders that have diverse etiologies but the same hallmark brain lesions. Since oxidative stress may play a role in the pathogenesis of AD and isoprostanes are chemically stable peroxidation products of arachidonic acid, we measured both iPF(2 alpha)-III and iPF(2 alpha)-VI using gas chromatography-mass spectrometry in AD and control brains. The levels of both isoprostanes, but not of 6-keto PGF(1 alpha), an index of prostaglandin production, were markedly elevated in both frontal and temporal poles of AD brains compared to the corresponding cerebella. Levels were also elevated compared to corresponding areas of brains from patients who had died with schizophrenia or Parkinson's disease or from nonneuropsychiatric disorders, iPF(2 alpha) -IV, but not iPF(2 alpha)-III, levels were higher in ventricular CSF of AD brains relative to the non-AD brains. These data suggest that specific isoprostane analysis may reflect increased oxidative stress in AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:02:56