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Titolo:
Depletion of acinar secretory granules in the ferret parotid gland: Effects of substance P and vasoactive intestinal peptide
Autore:
Ekstrom, J; Ekstrom, PF;
Indirizzi:
Univ Gothenburg, Dept Pharmacol, SE-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-40530 , SE-40530 Gothenburg, Sweden Dent Publ Serv Clin, Kungshamn, Sweden Dent Publ Serv Clin Kungshamn Sweden Publ Serv Clin, Kungshamn, Sweden
Titolo Testata:
EXPERIMENTAL PHYSIOLOGY
fascicolo: 6, volume: 83, anno: 1998,
pagine: 727 - 735
SICI:
0958-0670(199811)83:6<727:DOASGI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARASYMPATHETIC NERVE-STIMULATION; RAT SALIVARY-GLANDS; PROTEIN SECRETION; SUPER-SENSITIVITY; REFLEX SECRETION; INNERVATION; ATROPINE; AMYLASE; INVIVO; FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ekstrom, J Univ Gothenburg, Dept Pharmacol, Box 431, SE-40530 Gothenburg, Sweden Univ Gothenburg Box 431 Gothenburg Sweden SE-40530 urg, Sweden
Citazione:
J. Ekstrom e P.F. Ekstrom, "Depletion of acinar secretory granules in the ferret parotid gland: Effects of substance P and vasoactive intestinal peptide", EXP PHYSIOL, 83(6), 1998, pp. 727-735

Abstract

The acinar cells of the ferret parotid gland are supplied with parasympathetic nerve fibres containing vasoactive intestinal peptide (VIP) and substance P. In this study intracarotid infusions of the two peptides (05-1.0 mu g kg(-1) min(-1) of each for 40 min) in the pentobarbitone-anaesthetized ferret, treated with atropine and adrenoceptor antagonists, induced a loss ofacinar secretory granules from this gland, by 32% in response to VIP and by 46% in response to substance P. Stimulation of the parasympathetic auriculo-temporal nerve (40 Hz, in the presence of adrenoceptor antagonists) caused a larger loss of acinar granules from the gland than stimulation of the sympathetic superior cervical ganglion (intermittently, 50 Hz for 1 s every10th second, in the presence of atropine) over 40 min (52 % versus 10 %). A 27 % granular loss in response to parasympathetic stimulation followed upon atropinization. The parasympathetic response was not further diminished by the tachykinin antagonist Spantide ((D-Arg(1),D-Pro(2), D-Trp(7,9),Leu)-substance P). Thus, despite the large exocytotic response to the infusion of substance P, the parasympathetic non-adrenergic, non-cholinergic secretion of storage granules seemed, under the present experimental conditions, tooccur independently of the action of substance P.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:50:35