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Titolo:
Differential influence of a selective melanocortin MC4 receptor antagonist(HS014) on melanocortin-induced behavioral effects in rats
Autore:
Vergoni, AV; Bertolini, A; Mutulis, F; Wikberg, JES; Schioth, HB;
Indirizzi:
UppsalanUniv, Biomed Ctr, Dept Pharmaceut Pharmacol, S-75124 Uppsala, Swede Uppsala Univ Uppsala Sweden S-75124 ut Pharmacol, S-75124 Uppsala, Swede Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy Latvian Acad Sci, Inst Organ Synth, Dept Med Chem, LV-226006 Riga, Latvia Latvian Acad Sci Riga Latvia LV-226006 Med Chem, LV-226006 Riga, Latvia
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 362, anno: 1998,
pagine: 95 - 101
SICI:
0014-2999(199812)362:2-3<95:DIOASM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING-HORMONE RECEPTOR; MOLECULAR-CLONING; ALPHA-MSH; FEEDING-BEHAVIOR; PEPTIDES; ACTH; OBESITY; ANALOGS; LOCALIZATION; ACTH-(1-24);
Keywords:
melanocortin receptor; MSH (melanocyte-stimulating hormone); HS014; food intake; grooming behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schioth, HB Uppsalala,iv, Biomed Ctr, Dept Pharmaceut Pharmacol, Box 591, S-75124 Uppsa Uppsala Univ Box 591 Uppsala Sweden S-75124 91, S-75124 Uppsa
Citazione:
A.V. Vergoni et al., "Differential influence of a selective melanocortin MC4 receptor antagonist(HS014) on melanocortin-induced behavioral effects in rats", EUR J PHARM, 362(2-3), 1998, pp. 95-101

Abstract

We injected i.c.v. the natural agonist alpha-MSH (melanocyte-stimulating hormone) and the first selective melanocortin MC, receptor antagonist HS014 (cyclic [AcCys(11), D-Nal(14), Cys(18), Asp-NH222]-beta-MSH(11-22) in rats and scored a number of behavioral effects which have been related to the melanocortic peptides. The results showed that HS014 (5 mu g/rat) completely blocked alpha-MSH (3 and 5 mu g/rat)-induced grooming, yawning and stretching. Penile erections induced by alpha-MSH were, however, only partially blocked by HS014. Injections of alpha-MSH decreased food intake in food-deprived rats, whereas HS014 increased food intake. When the peptides were given together, the food intake was similar to that of saline treated controls. Locomotion/exploration and resting were not influenced by either peptide. Our data show that exogenous alpha-MSH decreases food intake, and that an endogenous central melanocortinergic inhibitory tone on feeding prevails whichcan be blocked with HS014, leading to an increase in food intake. Our dataalso provide evidence that grooming, stretching and yawning in rats may bemediated by the melanocortin MC, receptor, whereas penile erections might perhaps be mediated by some other melanocortin receptor. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:48:16