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Titolo:
The combined inactivation of tumor necrosis factor and interleukin-6 prevents induction of the major acute phase proteins by endotoxin
Autore:
Bopst, M; Haas, C; Car, B; Eugster, HP;
Indirizzi:
UnivtzerlandHosp, Dept Internal Med, Clin Immunol Sect, CH-8044 Zurich, Swi Univ Zurich Hosp Zurich Switzerland CH-8044 ol Sect, CH-8044 Zurich, Swi Univ Zurich Irchel, Inst Anat, CH-8057 Zurich, Switzerland Univ Zurich Irchel Zurich Switzerland CH-8057 H-8057 Zurich, Switzerland Swiss Fed Inst Technol, Inst Toxicol, Schwerzenbach, Switzerland Swiss FedInst Technol Schwerzenbach Switzerland erzenbach, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 12, volume: 28, anno: 1998,
pagine: 4130 - 4137
SICI:
0014-2980(199812)28:12<4130:TCIOTN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM AMYLOID-A; INFLAMMATORY RESPONSE; FACTOR-ALPHA; INTERLEUKIN-1-BETA-DEFICIENT MICE; LYMPHOTOXIN-ALPHA; DEFICIENT MICE; RECEPTOR; CYTOKINES; DEPOSITS; IMMUNE;
Keywords:
acute phase response; cytokine; TNF; serum amyloid A; serum amyloid P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Eugster, HP Univ044rich Hosp, Dept Internal Med, Clin Immunol Sect, Moussonstr 13, CH-8 Univ Zurich Hosp Moussonstr 13 Zurich Switzerland CH-8044 H-8
Citazione:
M. Bopst et al., "The combined inactivation of tumor necrosis factor and interleukin-6 prevents induction of the major acute phase proteins by endotoxin", EUR J IMMUN, 28(12), 1998, pp. 4130-4137

Abstract

The constellation of changes known as the acute phase response (APR) is a cytokine-driven process initiated by tissue inflammation. The proinflammatory cytokines, TNF, IL-1 and IL-6, are considered to be the primary mediators of the APR. IL-6 and IL-1 beta gene-deleted mice (Fattori et al., J. Exp. Med. 1994. 180: 1243-1250; Kopf et al., Nature 1994. 368: 339-342; Fantuzzi et al., J. Immunol. 1996. 157: 291-296, respectively), exhibit impaired APR to turpentine injection but only a slight reduction in plasma acute phase protein levels in response to lipopolysaccharide (LPS). This infers an important role for TNF in the LPS-induced APR, however, in the present study,normal APR to both turpentine and LPS were observed in TNF/LT alpha-deficient mice. A striking absence of elevated major acute phase proteins, SAP and SAA, was observed in mice deficient in TNF/LT alpha and IL-6, suggesting that TNF-alpha or LT alpha do indeed exert important nonredundant synergismin the IL-1/IL-6 primary response. The regulation of other parameters typically altered in an APR, body weight, blood glucose and haptoglobin, was normal in LPS-dosed TNF/LT alpha-deficient and wild-type mice. The observed transcriptional response for SAA and SAP in these TNF/LT alpha/IL-6-deficient mice, in lieu of elevated plasma revels, suggests that SAA and SAP expression is possibly posttranscriptionally regulated.

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Documento generato il 27/01/21 alle ore 03:03:14