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Titolo:
Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation
Autore:
Lin, CL; Suri, RM; Rahdon, RA; Austyn, JM; Roake, JA;
Indirizzi:
Univndxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, Engla Univ Oxford Oxford England OX3 9DU ield Dept Surg, Oxford OX3 9DU, Engla
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 12, volume: 28, anno: 1998,
pagine: 4114 - 4122
SICI:
0014-2980(199812)28:12<4114:DCCATM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LANGERHANS CELL; FACTOR-ALPHA; NONLYMPHOID TISSUES; IN-VITRO; RECEPTOR; EXPRESSION; LIPOPOLYSACCHARIDE; PATTERNS; LYMPH;
Keywords:
dendritic cell; chemotaxis; transendothelial migration; chemokine; maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Austyn, JM Univndxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, Engla Univ Oxford Oxford England OX3 9DU urg, Oxford OX3 9DU, Engla
Citazione:
C.L. Lin et al., "Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation", EUR J IMMUN, 28(12), 1998, pp. 4114-4122

Abstract

The capacity of dendritic cells (DC) to initiate immune responses is dependent on their specialized migratory and tissue homing properties. Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. immature DC were generated by culture of human monocytes in granulocyte-macrophagecolony-stimulating factor and IL-4. These cells exhibited potent chemotaxis and TEM responses to the CC chemokines macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, RANTES, and monocyte chemotactic protein-3, and weak responses to the CC chemokine MIP-3 beta and the CXC chemokine stromal cell-derived factor (SDF)-1 mu. Maturation of DG induced by culture in lipopolysaccharide, TNF-alpha or IL-1 beta reduced or abolished responses to theformer CC chemokines but markedly enhanced responses to MIP-3 beta and SDF-1 alpha. This correlated with changes in chemokine receptor expression: CCR5 expression was reduced while CXCR4 expression was enhanced. These findings suggest two stages for regulation of DC migration in which one set of chemokines may regulate recruitment into or within tissues, and another egress from the tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:12:58