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Titolo:
Prospects for gene therapy of insulin-dependent diabetes mellitus
Autore:
Efrat, S;
Indirizzi:
Teliv,iv Univ, Sackler Sch Med, Dept Human Genet & Mol Med, IL-69978 Tel Av Tel Aviv Univ Tel Aviv Israel IL-69978 Genet & Mol Med, IL-69978 Tel Av Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 harmacol, Bronx, NY 10467 USA
Titolo Testata:
DIABETOLOGIA
fascicolo: 12, volume: 41, anno: 1998,
pagine: 1401 - 1409
SICI:
0012-186X(199812)41:12<1401:PFGTOI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC BETA-CELLS; CONFER IMMUNE PRIVILEGE; HUMAN FETAL PANCREAS; TRANSGENIC MICE; AUTOIMMUNE DESTRUCTION; DUCTAL EPITHELIUM; ISLET ALLOGRAFTS; HUMAN PROINSULIN; GROWTH-FACTOR; AR42J CELLS;
Keywords:
beta-cell lines; conditional transformation; gene transfer; glucose-regulated promoters; immunomodulation; insulin biosynthesis; insulin secretion; islet regeneration; proinsulin processing; transplantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Efrat, S Teliv,iv Univ, Sackler Sch Med, Dept Human Genet & Mol Med, IL-69978 Tel Av Tel Aviv Univ Tel Aviv Israel IL-69978 Mol Med, IL-69978 Tel Av
Citazione:
S. Efrat, "Prospects for gene therapy of insulin-dependent diabetes mellitus", DIABETOLOG, 41(12), 1998, pp. 1401-1409

Abstract

The application of gene therapy to Type I (insulin-dependent) diabetes mellitus awaits improvements in gene transfer technologies and the developmentof better tools for accurate diagnosis of pre-diabetic people. Identification of the most promising candidate genes for gene transfer requires further elucidation of the molecular events involved in beta-cell autoimmune destruction, islet ontogeny and differentiation, and beta-cell function. This review outlines a number of possible targets for gene therapy in Type I diabetes, which could help prevent the autoimmune damage to islets, induce islet regeneration, and restore insulin production through engineering of self non-beta cells or beta-cell transplantation. It also evaluates their potential merits and drawbacks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:55:49