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Titolo:
CYTOKINE SIGNALING THROUGH THE NOVEL TYROSINE KINASE RAFTK IN KAPOSIS-SARCOMA CELLS
Autore:
LIU ZY; GANJU RK; WANG GF; ONA MA; HATCH WC; ZHENG T; AVRAHAM S; GILL P; GROOPMAN JE;
Indirizzi:
HARVARD UNIV,INST MED,SCH MED,DIV EXPT MED,BETH ISRAEL MED CTR,W CAMPUS,1 DEACONESS RD BOSTON MA 02215 HARVARD UNIV,INST MED,SCH MED,DIV EXPT MED,BETH ISRAEL MED CTR BOSTONMA 02215 HARVARD UNIV,SCH MED,DIV HEMATOL ONCOL,BETH ISRAEL MED CTR BOSTON MA 02215 UNIV SO CALIF,KENNETH NORRIS JR COMPREHENS CANC CTR,DIV HEMATOL ONCOLLOS ANGELES CA 90033
Titolo Testata:
The Journal of clinical investigation
fascicolo: 7, volume: 99, anno: 1997,
pagine: 1798 - 1804
SICI:
0021-9738(1997)99:7<1798:CSTTNT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; JUN ACTIVATION DOMAIN; TYPE-1 TAT PROTEIN; GROWTH-FACTOR; ONCOSTATIN-M; GENE-EXPRESSION; ENDOTHELIAL-CELLS; AIDS; IDENTIFICATION; PHOSPHORYLATION;
Keywords:
RAFTK; RELATED ADHESION FOCAL TYROSINE KINASE; KAPOSIS SARCOMA (KS); CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
Z.Y. Liu et al., "CYTOKINE SIGNALING THROUGH THE NOVEL TYROSINE KINASE RAFTK IN KAPOSIS-SARCOMA CELLS", The Journal of clinical investigation, 99(7), 1997, pp. 1798-1804

Abstract

A number of cytokines, including basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), oncostatin M (OSM), IL-6, and tumor necrosis factor alpha (TNF-alpha), have been postulated tohave a role in the pathogenesis of Kaposi's sarcoma (KS). The proliferative effects of bFGF and OSM may be via their reported activation ofthe c-Jun NH2-terminal kinase (JNK) signaling pathway in KS cells, Wenow report that KS cells express a recently identified focal adhesionkinase termed RAFTK which appears in other cell systems to coordinatesurface signals between cytokine and integrin receptors and the cytoskeleton as well as act downstream to modulate JNK activation. We also report that the tyrosine kinase receptor FLT-4, present on normal lymphatic endothelium, is robustly expressed in KS cells, Treatment of KS cells with VEGF-related protein (VRP), the ligand for the FLT-4 receptor, as well as with the cytokines bFGF, OSM, IL-6, VEGF, or TNF-alpha resulted in phosphorylation and activation of RAFTK, Following its activation, there was an enhanced association of RAFTK with the cytoskeletal protein paxillin. This association was mediated by the hydrophobicCOOH-terminal domain of the kinase, Furthermore, JNK activity was increased in KS cells after VEGF or VRP stimulation, We postulate that inthese tumor cells RAFTK may be activated by a diverse group of stimulatory cytokines and facilitate signal transduction to the cytoskeletonand downstream to the growth promoting JNK pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 05:53:35