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Titolo:
A NUCLEOTIDE SUBSTITUTION IN THE PROMOTER OF HUMAN ANGIOTENSINOGEN ISASSOCIATED WITH ESSENTIAL-HYPERTENSION AND AFFECTS BASAL TRANSCRIPTION IN-VITRO
Autore:
INOUE I; NAKAJIMA T; WILLIAMS CS; QUACKENBUSH J; PURYEAR R; POWERS M; CHENG T; LUDWIG EH; SHARMA AM; HATA A; JEUNEMAITRE X; LALOUEL JM;
Indirizzi:
UNIV UTAH,HLTH SCI CTR,HOWARD HUGHES MED INST,ECCLES INST HUMAN GENET,6TH FLOOR SALT LAKE CITY UT 84112 UNIV UTAH,HLTH SCI CTR,HOWARD HUGHES MED INST,ECCLES INST HUMAN GENETSALT LAKE CITY UT 84112 UNIV UTAH,HLTH SCI CTR,DEPT HUMAN GENET SALT LAKE CITY UT 84112 FREE UNIV BERLIN,DEPT GEN INTERNAL MED & NEPHROL D-12200 BERLIN GERMANY HOKKAIDO UNIV,SCH MED,DEPT PUBL HLTH SAPPORO HOKKAIDO 070 JAPAN HOP BROUSSAIS,INSERM U36 F-75005 PARIS FRANCE HOP BROUSSAIS,MOL BIOL LAB F-75005 PARIS FRANCE
Titolo Testata:
The Journal of clinical investigation
fascicolo: 7, volume: 99, anno: 1997,
pagine: 1786 - 1797
SICI:
0021-9738(1997)99:7<1786:ANSITP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; GENE; PREECLAMPSIA; MUTATIONS; MECHANISM; CLONING; PROTEIN; SYSTEM; SALT;
Keywords:
ESSENTIAL HYPERTENSION; ANGIOTENSINOGEN; MOLECULAR VARIANT; PROMOTER; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
I. Inoue et al., "A NUCLEOTIDE SUBSTITUTION IN THE PROMOTER OF HUMAN ANGIOTENSINOGEN ISASSOCIATED WITH ESSENTIAL-HYPERTENSION AND AFFECTS BASAL TRANSCRIPTION IN-VITRO", The Journal of clinical investigation, 99(7), 1997, pp. 1786-1797

Abstract

In earlier studies, we provided statistical evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive hormone angiotensin II, constitute inherited predispositions to essential hypertension in humans (1). We have now identified a common variant in the proximal promoter, the presence of an adenine, instead of a guanine, 6 bp upstream from the initiation site of transcription, insignificant association with the disorder, Tests of promoter activityand DNA binding studies with nuclear proteins suggest that this nucleotide substitution affects the basal transcription rate of the gene. These observations provide some biological insight about the possible mechanism of a genetic predisposition to essential hypertension; they may also have important evolutionary implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 16:18:59