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Titolo:
CARDIOVASCULAR EFFECTS OF MICROINJECTION OF LOW-DOSES OF SEROTONIN INTO THE NTS OF UNANESTHETIZED RATS
Autore:
CALLERA JC; BONAGAMBA LGH; SEVOZ C; LAGUZZI R; MACHADO BH;
Indirizzi:
UNIV SAO PAULO,DEPT PHYSIOL,SCH MED RIBEIRAO PRETO BR-14049900 RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,DEPT PHYSIOL,SCH MED RIBEIRAO PRETO BR-14049900 RIBEIRAO PRET SP BRAZIL CHU PITIE SALPETRIERE,INSERM U288 F-75634 PARIS 13 FRANCE
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 41, anno: 1997,
pagine: 1135 - 1142
SICI:
0363-6119(1997)41:4<1135:CEOMOL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; CONSCIOUS RATS; L-GLUTAMATE; NODOSE GANGLIA; RECEPTORS; STIMULATION; RESPONSES; IMMUNOREACTIVITY; MECHANISMS; PRESSURE;
Keywords:
HEART RATE; AUTONOMIC NERVOUS SYSTEM; PERIPHERAL CHEMORECEPTORS; ARTERIAL BARORECEPTORS; SEROTONIN RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Callera et al., "CARDIOVASCULAR EFFECTS OF MICROINJECTION OF LOW-DOSES OF SEROTONIN INTO THE NTS OF UNANESTHETIZED RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 41(4), 1997, pp. 1135-1142

Abstract

In the present study, we analyzed in conscious rats the effects of microinjections of serotonin (5-HT; pmol range) into the nucleus of the solitary tract (NTS) on basal mean arterial pressure (MAP) and heart rate (HR) and also on the reflex bradycardia induced by the activation of the baro- and chemoreflex evaluated 1 min after 5-HT microinjectioninto the NTS. The data show that unilateral microinjection of 5-HT inthe picomolar range into the NTS of unanesthetized rats produced a dose-dependent decrease in MAP and HR, which was blocked by previous microinjection of ketanserin (250 pmol/50 nl) into the NTS. The changes in MAP and HR induced by 5-HT were of very short duration, with a return to baseline values a few seconds later. The cardiovascular responsesto bare- or chemoreflex activation 1 min after 5-HT microinjection into the NTS did not differ from the control, indicating that low doses of 5-HT produced no effect on the cardiovascular reflexes tested at that time. The present data show that, as also observed in anesthetized rats, the microinjection of picomolar doses of 5-HT into the NTS elicits the typical cardiovascular responses to baroreceptor activation. These effects, hypotension and bradycardia, seem to be mediated by 5-HT2receptors because both were blocked by a selective 5-HT2 receptor antagonist. However, since microinjection of 5-HT (1 pmol) into the NTS produced no changes in the cardiovascular responses to the bare- and chemoreflex activated 1 min later, the role of 5-HT2 receptors in the processing of the cardiovascular afferent messages in the NTS remains tobe elucidated.

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Documento generato il 02/12/20 alle ore 14:55:15