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Titolo:
Nicotine enhances presynaptic and postsynaptic glutamatergic neurotransmission to activate cardiac parasympathetic neurons
Autore:
Neff, RA; Humphrey, J; Mihalevich, M; Mendelowitz, D;
Indirizzi:
Univ Tennessee, Dept Physiol & Biophys, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 siol & Biophys, Memphis, TN 38163 USA
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 12, volume: 83, anno: 1998,
pagine: 1241 - 1247
SICI:
0009-7330(199812)83:12<1241:NEPAPG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANT-DEATH-SYNDROME; ACETYLCHOLINE-RECEPTORS; ALPHA-BUNGAROTOXIN; BRADYCARDIA; MODULATION; MECHANISMS; NUCLEUS; RATS;
Keywords:
cardiac; parasympathetic; vagal; nicotine; brain stem; sudden infant death syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Mendelowitz, D UnivATennessee, Dept Physiol & Biophys, 894 Union Ave, Memphis, TN 38163 US Univ Tennessee 894 Union Ave Memphis TN USA 38163 38163 US
Citazione:
R.A. Neff et al., "Nicotine enhances presynaptic and postsynaptic glutamatergic neurotransmission to activate cardiac parasympathetic neurons", CIRCUL RES, 83(12), 1998, pp. 1241-1247

Abstract

Although peripheral cholinergic neurotransmission has long been known to play a pivotal role in the control of heart rate and blood pressure, recent evidence has suggested that central cholinergic mechanisms may be involved in the genesis of hypertension, anxiety, cardiorespiratory control, and, inparticular, the respiratory modulation of heart rate. Yet, the sites, mechanisms, and receptor subtypes involved in the action of nicotine within thecentral nervous system are controversial. The present study demonstrates that nicotine has at least 3 sites of action to increase the activity of vagal cardiac neurons. Nicotine, but not muscarinic agonists, activates postsynaptic receptors and a depolarizing inward current in vagal cardiac neuronsstudied with the perforated patch-clamp technique in a visualized brain stem slice. Ln addition, nicotine acts at different presynaptic and postsynaptic sites to facilitate glutamatergic neurotransmission. Presynaptic nicotinic receptors increase the frequency of transmitter release and are sensitive to block by cu-bungarotoxin. Nicotine also elicits a previously undescribed augmentation of postsynaptic non-NMDA currents. The presynaptic and postsynaptic receptors may prove to be future targets in the search for agonists to increase vagal cardiac activity and reduce the fatality associated with cardiac hyperexcitability and for antagonists to reduce cardiac vagal activity in pathological conditions associated with abnormally low heart rates and cardiac function such as sudden infant death syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:36:37