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Titolo:
The endothelin system in human and monkey ovaries: in situ gene expressionof the different components
Autore:
Karam, H; Valdenaire, O; Belair, MF; Prigent-Sassy, C; Rakotosalama, A; Clozel, M; Itskovitz, J; Bruneval, P;
Indirizzi:
Hop Broussais, INSERM, U430, F-75014 Paris, France Hop Broussais Paris France F-75014 , INSERM, U430, F-75014 Paris, France Hoffmann La Roche, Div Pharma, Preclin Res, CH-4070 Basel, Switzerland Hoffmann La Roche Basel Switzerland CH-4070 , CH-4070 Basel, Switzerland Rambam Med Ctr, Dept Obstet & Gynecol, IL-31096 Haifa, Israel Rambam Med Ctr Haifa Israel IL-31096 t & Gynecol, IL-31096 Haifa, Israel Technion Israel Inst Technol, Fac Med, IL-31096 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-31096 L-31096 Haifa, Israel
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 1, volume: 295, anno: 1999,
pagine: 101 - 109
SICI:
0302-766X(199901)295:1<101:TESIHA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORCINE GRANULOSA-CELLS; CONVERTING ENZYME; BLOOD-PRESSURE; B-RECEPTOR; LOCALIZATION; RENIN; CLONING; METALLOPROTEASE; STEROIDOGENESIS; HYBRIDIZATION;
Keywords:
endothelin; endothelin receptors; endothelin-converting enzyme; ovary; in situ hybridization; human; cynomolgus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Bruneval, P Hop Broussais, INSERM, U430, 96 Rue Didot, F-75014 Paris, France Hop Broussais 96 Rue Didot Paris France F-75014 Paris, France
Citazione:
H. Karam et al., "The endothelin system in human and monkey ovaries: in situ gene expressionof the different components", CELL TIS RE, 295(1), 1999, pp. 101-109

Abstract

The endothelin system is composed of three endothelin isoforms (ET-1, ET-2, and ET-3), the endothelin receptors ETA and ETB, and the endothelin-converting enzyme (ECE). Besides having a major vasoactive role, endothelins have roles in different cell types at a local level. We investigated the presence of the different components of the endothelin system in primate ovaries. Human Introduction ovaries and gonadotropin-stimulated monkey ovaries were studied using immunohistochemistry for endothelin, and in situ hybridization with probes for ET-1, ET-2, ET-3, ETA and ETB receptors, and ECE. ET-1 and ETA receptors were detected in endothelial cells and vascular smooth muscle cells, respectively, in stromal vessels adjacent to follicles and corpora lutea. ETB receptors and ET-1 were found in the endothelial cells of capillaries of corpora lutea. ECE was present in internal theca cells of secondary, de Graaf, atretic follicles, and in luteinized granulosa cells of the corpora lutea. The endothelin system components are present in or around the follicles of human and monkey ovaries. Although the components are not expressed in the same cell types, they are synthesized, mainly in follicles, by cells that are in close proximity. Thus, the endothelin system could act in a paracrine manner. ECE expression in steroid-producing cells changesits compartmentalization during follicle maturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:12:26