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Titolo:
Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit
Autore:
Cellek, S; Moncada, S;
Indirizzi:
Univ Coll London, Wolfson Inst Biomed Res, London W1P 9LN, England Univ Coll London London England W1P 9LN med Res, London W1P 9LN, England
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 8, volume: 125, anno: 1998,
pagine: 1627 - 1629
SICI:
0007-1188(199812)125:8<1627:NNMTNN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; PENILE ERECTION; PHYSIOLOGY; INHIBITION; CYCLASE;
Keywords:
nitrergic; nitric oxide; clitoris; corpus cavernosum; rabbit; non-adrenergic non-cholinergic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Cellek, S Univ1Poll London, Wolfson Inst Biomed Res, 140 Tottenham Court Rd, London W Univ Coll London 140 Tottenham Court Rd London England W1P 9LN
Citazione:
S. Cellek e S. Moncada, "Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit", BR J PHARM, 125(8), 1998, pp. 1627-1629

Abstract

The corpus cavernosum is the erectile tissue in the penis and clitoris. Although nitrergic neurotransmission has been characterized in detail in the penile corpus cavernosum, functional studies on the inhibitory non-adrenergic non-cholinergic (NANC) transmission in the clitoral corpus cavernosum have been lacking. Here we demonstrate that electrical field stimulation (EFS) induces NANC relaxation responses in the clitoral corpus cavernosum of the rabbit. These responses were inhibited by N-G-nitro-L-arginine methylester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ) or tetrodotoxin. The inhibitory effect of L-NAME was partially reversed by L-arginine but not by D-arginine. EFS-induced relaxations were enhanced by an inhibitorof type V cyclic GMP phosphodiesterase, zaprinast. These results suggest that nitrergic neurotransmission is responsible for the NANC relaxation responses in the clitoral corpus cavernosum of the rabbit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 09:51:36