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Titolo:
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction
Autore:
Liu, ZJ; Tanaka, Y; Mine, S; Morinobu, A; Yagita, H; Okumura, K; Taniguchi, T; Yamamura, H; Minami, Y;
Indirizzi:
Kobe Univ, Sch Med, Dept Biochem, Chuo Ku, Kobe, Hyogo 6500017, Japan KobeUniv Kobe Hyogo Japan 6500017 m, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ, Sch Med, Dept Lab Med, Chuo Ku, Kobe, Hyogo 6500017, Japan KobeUniv Kobe Hyogo Japan 6500017 d, Chuo Ku, Kobe, Hyogo 6500017, Japan Univuokaupat & Environm Hlth, Sch Med, Dept Internal Med 1, Kitakyushu, Fuk Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 807 Kitakyushu, Fuk Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 v, Sch Med, Dept Immunol, Tokyo 113, Japan JST, CREST, Tokyo, Japan JST Tokyo JapanJST, CREST, Tokyo, Japan Univ Tokyo, Fac Med, Dept Immunol, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 okyo, Fac Med, Dept Immunol, Tokyo 113, Japan
Titolo Testata:
BLOOD
fascicolo: 12, volume: 92, anno: 1998,
pagine: 4700 - 4711
SICI:
0006-4971(199812)92:12<4700:FCOCCA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCE; INTEGRIN VLA-4; LYMPHOCYTE ADHESION; CYTOPLASMIC DOMAIN; PROTEIN-KINASE; BETA-SUBUNIT; EXTRACELLULAR-MATRIX; LEUKOCYTE INTEGRINS; MONOCLONAL-ANTIBODY; SIGNALING PATHWAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Minami, Y Kobe500017,Sch Med, Dept Biochem, Chuo Ku, 7-5-1 Kusunokicho, Kobe, Hyogo 6 Kobe Univ 7-5-1 Kusunokicho Kobe Hyogo Japan 6500017 be, Hyogo 6
Citazione:
Z.J. Liu et al., "Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction", BLOOD, 92(12), 1998, pp. 4700-4711

Abstract

Very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) area pair of adhesion molecules mediating cell-cell interaction. The binding activity of each depends on its surface expression, yet integrin activity can also be modulated through inside-out signaling. However, the specific intracellular molecules involved in modulating integrin VLA-4 activation via inside-out signaling or in regulating VCAM-1 expression are poorly understood. We show here that constitutive coexpression of cyclin C and c-Myc in hematopoietic BAF-B03 cells induces homotypic cell adhesion, which results from enhanced VLA-4 ligand-binding activity and induced expression of VCAM-1. Furthermore, regulation of cell adhesion appears to be a feature unique tocyclin C, but not other G1 cyclins, E and D3, and its regulatory function is independent of CDK8 kinase activity. Our results provide a novel role for cyclin C and c-Myc in the regulation of cell adhesion through distinct mechanisms. (C) 1998 by The American Society of Hematology.

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Documento generato il 04/07/20 alle ore 14:25:44