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Titolo:
Are different parts of the extended amygdala involved in fear versus anxiety?
Autore:
Davis, M;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yaleven,v, Sch Med, Connecticut Mental Hlth Ctr, Ribicoff Res Facil, New Ha Yale Univ New Haven CT USA t Mental Hlth Ctr, Ribicoff Res Facil, New Ha
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 12, volume: 44, anno: 1998,
pagine: 1239 - 1247
SICI:
0006-3223(199812)44:12<1239:ADPOTE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; ACOUSTIC STARTLE REFLEX; STIMULUS REWARD ASSOCIATIONS; ELECTRICALLY-EVOKED STARTLE; RETICULARIS PONTIS CAUDALIS; BLOCK CONDITIONED FEAR; POTENTIATED STARTLE; CENTRAL NUCLEUS; LATERAL LEMNISCUS; VENTRAL STRIATUM;
Keywords:
startle; bed nucleus of the stria terminalis; conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, M Emory Univ, Sch Med, 1639 Pierce Dr,Suite 4000, Atlanta, GA 30322USA Emory Univ 1639 Pierce Dr,Suite 4000 Atlanta GA USA 30322 322 USA
Citazione:
M. Davis, "Are different parts of the extended amygdala involved in fear versus anxiety?", BIOL PSYCHI, 44(12), 1998, pp. 1239-1247

Abstract

Although there is a close correspondence between fear and anxiety and the study of fear in animals has been extremely valuable for understanding brain systems that are important for anxiety, it is equally clear that a richeranimal model of human anxiety disorders would include measures of both stimulus-specific fear and something less stimulus specific, more akin to anxiety. Studies in patients with posttraumatic stress syndrome indicate these individuals seem to show normal fear reactions but abnormal anxiety measured with the acoustic startle reflex. Studies in rats, also using the startlereflex, indicate that highly processed explicit cue information (lights, tones, touch) activates the central nucleus of the amygdala, which ill turn activates hypothalamic and brain stem target areas involved in specific signs of fear. Somewhat less explicit information, such as that produced by exposure to a threating environment for several minutes or by intraventricular administration of the peptide corticotropin-releasing hormone may activate a brain area closely related to the amygdala, called the bed nucleus of the stria terminalis, which in turn activates hypothalamic and brain stem target areas involved in specific signs of fear or anxiety. Because the nature of this information may be less specific than that produced by an explicit cue, and of much longer duration, activation of the bed nucleus of the stria terminalis may be mope akin to anxiety than to fear. Biol Psychiatry 1998;44:1239-1247 (C) 1998 Society of Biological Psychiatry.

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Documento generato il 25/01/20 alle ore 06:19:27