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Titolo:
Differential alterations in basal and D-amphetamine-induced behavioural pattern following 6-OHDA or ibotenic acid lesions into the dorsal striatum
Autore:
Antoniou, K; Papadopoulou-Daifotis, Z; Kafetzopoulos, E;
Indirizzi:
Univ Ioannina, Sch Med, Dept Pharmacol, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 rmacol, GR-45110 Ioannina, Greece Univ Athens, Sch Med, Dept Expt Pharmacol, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 pt Pharmacol, GR-11527 Athens, Greece
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 97, anno: 1998,
pagine: 13 - 28
SICI:
0166-4328(199812)97:1-2<13:DAIBAD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; NUCLEUS ACCUMBENS; DOPAMINE NEURONS; RAT-BRAIN; KAINIC ACID; TIME-COURSE; 6-HYDROXYDOPAMINE; APOMORPHINE; NEOSTRIATUM; STEREOTYPY;
Keywords:
D-amphetamine; ibotenic acid; 6-OHDA; dorsal striatum; behavioural pattern; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Antoniou, K Univ Ioannina, Sch Med, Dept Pharmacol, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 5110 Ioannina, Greece
Citazione:
K. Antoniou et al., "Differential alterations in basal and D-amphetamine-induced behavioural pattern following 6-OHDA or ibotenic acid lesions into the dorsal striatum", BEH BRA RES, 97(1-2), 1998, pp. 13-28

Abstract

It is well known that the corpus striatum is related to the sterotyped activation induced by several psychostimulants. In this study we analyzed the effects of 6-OHDA, in comparison with those of ibotenic acid lesions, into the dorsal striatum, on the behavioural pattern induced by saline or D-amphetamine treatment. A computerized technique for recording the animal motor activity was developed in order to define in a detailed way the behaviouralprofile in lesioned and sham-operated rats induced by the saline or D-amphetamine treatment. A 6-OHDA lesion into the dorsal striatum modified the basal behavioural pattern which was mainly characterized by reduced motor activation while ibotenic acid lesion affected the structure of the basal behavioral pattern. D-Amphetamine administration in 6-OHDA lesioned rats induced a behavioural stimulation, but a decreased motor and stereotyped activation was observed compared to the sham-operated animals treated with D-amphetamine. In contrast, D-amphetamine administration in the ibotenic acid-lesioned rats induced a motor and stereotyped activity which was not reduced compared to that seen after D-amphetamine treatment in sham-operated rats. These results suggest that these two types of lesion induced differential effects on the behavioural pattern either after saline or after D-amphelamine administration. Dopaminergic neurotransmission in the dorsal striatum plays a permissive role on the emergence of the behavioural responses, while the dorsal striatum circuitry plays a crucial role on the organization of the behavioural pattern. In addition, dopaminergic activity in this structure serves a primary control in the D-amphetamine-elicited motor activation or stereotypy, while the striatal structure is involved in the shaping of the D-amphetamine behavioural pattern. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 00:26:53