Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Risk factors for breakthrough varicella in healthy children
Autore:
Lim, YJ; Chew, FT; Tan, AYS; Lee, BW;
Indirizzi:
Natl Univ Singapore, Dept Paediat, Singapore 119074, Singapore Natl Univ Singapore Singapore Singapore 119074 ngapore 119074, Singapore
Titolo Testata:
ARCHIVES OF DISEASE IN CHILDHOOD
fascicolo: 6, volume: 79, anno: 1998,
pagine: 478 - 480
SICI:
0003-9888(199812)79:6<478:RFFBVI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIALS; VIRUS-VACCINE; OKA STRAIN; CHICKENPOX; ZOSTER; IMMUNIZATION; IMMUNITY; EFFICACY;
Keywords:
varicella; vaccination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, BW Natlingaporengapore, Dept Paediat, Lower Kent Ridge Rd, Singapore 119074, S Natl Univ Singapore Lower Kent Ridge Rd Singapore Singapore 119074
Citazione:
Y.J. Lim et al., "Risk factors for breakthrough varicella in healthy children", ARCH DIS CH, 79(6), 1998, pp. 478-480

Abstract

Aim-To evaluate the risk factors for breakthrough varicella in a follow upstudy of a cohort of 181 healthy children immunised when aged 9-24 months with a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka). Design-The children were randomised in a double blind manner into one of four groups to receive one of two production lot vaccine batches, at two different titres thigh titre, 10(3.9) and 10(4.0) plaque forming units (pfu); low titre (heat exposed), 10(2.7) and 10(2.8) pfu). The overall seroconversion rate after immunisation was 99%. Results-One hundred and sixty eight patients were available for review after a mean (SD) follow up of 35 (9) months after vaccination. Multivariate analysis indicated that risk factors for breakthrough varicella were household contact with varicella (adjusted odds ratio (OR), 19.89; 95% confidence interval (CI), 18.39 to 21.39), vaccination age of less than or equal to 14months (adjusted OR, 2.30; 95% CI, 1.69 to 2.90), and receiving low titre (10(2.7) pfu) vaccine (adjusted OR, 2.13; 95% CI, 1.54 to 2.73). All children who developed breakthrough varicella, had a modified varicella illness, except for three, all of whom had received low titre vaccine. Conclusion-The identification of young immunisation age (less than or equal to 14 months) and low titre vaccine as risk factors for breakthrough varicella have important implications for the implementation of varicella vaccination programmes in healthy children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 18:52:29