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Titolo:
THE PRODUCT OF THE PROTOONCOGENE C-CBL - A NEGATIVE REGULATOR OF THE SYK TYROSINE KINASE
Autore:
OTA Y; SAMELSON LE;
Indirizzi:
NICHHD,CELL BIOL & METAB BRANCH BETHESDA MD 20892 NICHHD,CELL BIOL & METAB BRANCH BETHESDA MD 20892
Titolo Testata:
Science
fascicolo: 5311, volume: 276, anno: 1997,
pagine: 418 - 420
SICI:
0036-8075(1997)276:5311<418:TPOTPC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-EPSILON-RI; SH3 DOMAIN; T-CELL; PROTOONCOGENE PRODUCT; EGF STIMULATION; JURKAT CELLS; V-CBL; RECEPTOR; PHOSPHORYLATION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ota e L.E. Samelson, "THE PRODUCT OF THE PROTOONCOGENE C-CBL - A NEGATIVE REGULATOR OF THE SYK TYROSINE KINASE", Science, 276(5311), 1997, pp. 418-420

Abstract

Engagement of antigen and immunoglobulin receptors on hematopoietic cells is directly coupled to activation of nonreceptor protein tyrosinekinases (PTKs) that then phosphorylate critical intracellular substrates. In mast cells stimulated through the Fc epsilon RI receptor, activation of several PTKs including Syk leads to degranulation and release of such mediators of the allergic response as histamine and serotonin. Regulation of Syk function occurred through interaction with the Cbl protein, itself a PTK substrate in this system. Overexpression of Cbl led to inhibition of Syk and suppression of serotonin release from mast cells, demonstrating its ability to inhibit a nonreceptor tyrosinekinase. Complex adaptor proteins such as Cbl can directly regulate the functions of the proteins they bind.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:33:35