Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bcl-2 and p53 expression in stage I endometrial carcinoma
Autore:
Giatromanolaki, A; Sivridis, E; Koukourakis, MI; Harris, AL; Gatter, KC;
Indirizzi:
Tumour & Angiogenesis Res Grp, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp Iraklion Crete Greece 71306 , Crete, Greece Democritusolisv Thrace, Univ Hosp Alexandroupolis, Dept Pathol, Alexandroup Democritus Univ Thrace Alexandroupolis Greece 68100 Pathol, Alexandroup UniveHosp Iraklion, Dept Radiotherapy & Oncol, Iraklion 71110, Crete, Greec Univ Hosp Iraklion Iraklion Crete Greece 71110 aklion 71110, Crete, Greec Oxford Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ ci, Oxford OX3 7LJ, England OxfordLJ,dcliffe Hosp, Imperial Canc Res Fund, Med Oncol Unit, Oxford OX3 7 Oxford Radcliffe Hosp Oxford England OX3 7LJ ed Oncol Unit, Oxford OX3 7
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 5B, volume: 18, anno: 1998,
pagine: 3689 - 3693
SICI:
0250-7005(199809/10)18:5B<3689:BAPEIS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; PROGNOSTIC INDICATOR; CANCER; ADENOCARCINOMA; PROTEIN; OVEREXPRESSION;
Keywords:
endometrial cancer; p53; bcl-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Giatromanolaki, A Tumourreecegiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, G Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "Bcl-2 and p53 expression in stage I endometrial carcinoma", ANTICANC R, 18(5B), 1998, pp. 3689-3693

Abstract

The role of p53 and bcl-2 apoptosis related proteins in the pathogenesis of endometrial cancer remains unclear.;We immunohistochemically examined 133surgically removed tumour specimens from patients with stage I endometrialcancer for p53 oncoprotein nuclear expression and bcl-2 cytoplasmic reactivity. 114/133 (86%) cases were of the endometrioid histological sub-type. Acut-off point of 10% of cells with strong reactivity was used for positivity. Positive p53 expression was observed in 12/133 (9%) and positive bcl-2 in 40/133 (30%) cases. p53 expression was not related to bcl-2 expression. No association of p53 and bcl-2 with depth of myometrial invasion, vascularinvasion or histological grade was observed. However, continuous variable analysis revealed a trend of low grade cases to have a higher percentage ofbcl-2 positive cells (16.3+27% vs. 7.8+16%; p=0.09, unpaired two tailed t-test). Interestingly, a statistically significant association of p53 positivity with age was also observed (p=0.03). A strong association of high grade with depth of myometrial invasion (p=0.006) and vascular invasion (p=0.0001) was also noticed. In addition, the presence of adenomyosis was also associated with low grade (p=0.01) and absence of vascular invasion (p=0.02). We conclude that although loss of bcl-2 protein expression and p53 mutant protein nuclear accumulation are early events in the endometrial cancer progression, histological grade and vascular invasion remain the most importantfactors defining local invasive behaviour of endometrial cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 17:37:33