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Titolo:
Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension
Autore:
Tuder, RM; Radisavljevic, Z; Shroyer, KR; Polak, JM; Voelkel, NF;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pathol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Pathol, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA Univ ColoradoDenver CO USA 80262 Sci Ctr, Dept Med, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Div Pulm Sci & Crit Care Med, Denver, CO 80262 Univ Colorado Denver CO USA 80262 m Sci & Crit Care Med, Denver, CO 80262 Univ Colorado, Hlth Sci Ctr, Pulm Hypertens Ctr, Denver, CO 80262 USA UnivColorado Denver CO USA 80262 ulm Hypertens Ctr, Denver, CO 80262 USA Univem,ndon Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Histoch Univ London Imperial Coll Sci Technol & Med London England Dept Histoch
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 6, volume: 158, anno: 1998,
pagine: 1999 - 2001
SICI:
1073-449X(199812)158:6<1999:MECIAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXFENFLURAMINE; FENFLURAMINE; LESIONS; ORIGIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Tuder, RM Univenver,ado, Hlth Sci Ctr, Dept Pathol, Campus Box B216,4200 E9th Ave, D Univ Colorado Campus Box B216,4200 E 9th Ave Denver CO USA 80262
Citazione:
R.M. Tuder et al., "Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension", AM J R CRIT, 158(6), 1998, pp. 1999-2001

Abstract

Anorexigens such as aminorex fumarate and dexfenfluramine are associated with the development of severe pulmonary hypertension (PH), which clinicallyand histopathologically is considered indistinguishable from idiopathic orprimary pulmonary hypertension (PPH). For the current study, we asked whether anorexigen-associated PH is characterized by monoclonal pulmonary endothelial cell proliferation (such as in PPH) or, alternatively, is associatedwith a polyclonal endothelial cell proliferation as found in secondary PH. Analysis of clonality by the human androgen receptor assay was performed in microdissected endothelial cells of plexiform lesions of two patients with anorexigen-associated PH. The four plexiform lesions of Patient 1 and thesix of Patient 2 with anorexigen-associated PH exhibited a monoclonal expansion of pulmonary endothelial cells, with a mean clonality ratio of 0.03 +/- 0.01 SE. Our results indicate that appetite suppressant-associated PH isidentical to PPH not only in clinical and histopathologic features but also, at a molecular level, in terms of the monoclonal nature of the endothelial cell proliferation. The anorexigens may accelerate the growth of pulmonary endothelial cells in patients with predisposition to develop PPH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:54:04