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Titolo:
Gestational age-dependent extravillous cytotrophoblast osteopontin immunolocalization differentiates between normal and preeclamptic pregnancies
Autore:
Gabinskaya, T; Salafia, CM; Gulle, VE; Holzman, IR; Weintraub, AS;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 ediat, New York, NY 10029 USA Montefiore Med Ctr, Dept Pathol, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 r, Dept Pathol, Bronx, NY 10467 USA Mt Sinai Sch Med, Dept Pathol, New York, NY USA Mt Sinai Sch Med New YorkNY USA Sch Med, Dept Pathol, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 40, anno: 1998,
pagine: 339 - 346
SICI:
1046-7408(199811)40:5<339:GAECOI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; IN-VITRO; ENDOVASCULAR INVASION; SIGNAL-TRANSDUCTION; BETA(3) INTEGRIN; MATRIX PROTEINS; ADHESION; EXPRESSION; TROPHOBLAST; MIGRATION;
Keywords:
extracellular matrix; invasion; vascular smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Weintraub, AS CUNY Mt Sinai Sch Med, Dept Pediat, Box 1508,1 Gustave L Levy Pl, New York, CUNY Mt Sinai Sch Med Box 1508,1 Gustave L Levy Pl New YorkNY USA 10029
Citazione:
T. Gabinskaya et al., "Gestational age-dependent extravillous cytotrophoblast osteopontin immunolocalization differentiates between normal and preeclamptic pregnancies", AM J REPROD, 40(5), 1998, pp. 339-346

Abstract

PROBLEM: Normal placentation requires modulation of proliferative cytotrophoblast to an invasive phenotype. Preeclampsia is characterized by failed cytotrophoblast invasion and arterial remodeling. Osteopontin (OPN) is an extracellular matrix protein implicated in cell adhesion, spreading, and invasion. METHOD OF STUDY: To investigate gestational age-related OPN expression, placental immunostaining was performed. To investigate the role of OPN in uteroplacental vascular pathology, placental immunostaining from pregnancies with preeclampsia (n = 12), fetal growth retardation (FGR) (n = 8), or both (n = 4) was compared with gestational age-matched controls (n = 24). RESULTS: In non-preeclamptic pregnancies, OPN immunolocalized to basal plate and intervillous cytotrophoblasts from 24-30 weeks (n = 13). In preeclampsia, OPN immunoreactivity was detected from 24-40 weeks. Cytotrophoblasts from FGR placentas were OPN-positive until 30 weeks, unless preeclampsia accompanied the FGR. In this case, cytotrophoblasts were OPN-positive from 24-40 weeks. CONCLUSIONS: The data suggest a role for OPN in cytotrophoblast invasion of the maternal vasculature/extracellular matrix during non-preeclamptic placentation, and OPN may serve as a marker for placental bed remodeling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:07:58