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Titolo:
Identification of the source of inhibins at the time of conception provides a diagnostic role for them in very early pregnancy
Autore:
Lockwood, GM; Ledger, WL; Barlow, DH; Groome, NP; Muttukrishna, S;
Indirizzi:
Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford, England Univ OxfordOxford England ield Dept Obstet & Gynaecol, Oxford, England Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England Oxford Brookes Univ Oxford England OX3 0BP Sci, Oxford OX3 0BP, England
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 40, anno: 1998,
pagine: 303 - 308
SICI:
1046-7408(199811)40:5<303:IOTSOI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MENSTRUAL-CYCLE; 2-SITE ENZYME-IMMUNOASSAY; DIMERIC INHIBIN; ACTIVIN-A; SERUM CONCENTRATIONS; FIRST-TRIMESTER; FORMS;
Keywords:
early pregnancy diagnosis; inhibin; pregnancy viability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lockwood, GM Johnndadcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, Engla John Radcliffe Hosp Oxford England OX3 9DU d OX3 9DU, Engla
Citazione:
G.M. Lockwood et al., "Identification of the source of inhibins at the time of conception provides a diagnostic role for them in very early pregnancy", AM J REPROD, 40(5), 1998, pp. 303-308

Abstract

PROBLEM: Early diagnosis of a complicated or poor pregnancy outcome in patients undergoing assisted reproductive technique (ART) fertility treatment could aid their counseling and management. A possible role for the inhibin superfamily as markers of early pregnancy viability was investigated. METHOD OF STUDY: To determine the source of the dimeric glycoproteins inhibin A (alpha-beta A) in early pregnancy, serial blood samples from women who became pregnant following in vitro fertilization (IVF) with fresh embryo transfer (n = 50), from women who achieved pregnancy with frozen-thawed embryos (n = 8), and from a control group of women with spontaneous conceptions (n = 7) were analyzed using a two-site enzyme-linked immunosorbent assay (ELISA). Gonadotropin-releasing hormone (GnRH) analogues are routinely usedin ART treatment cycles and are recognized to be luteolytic, and hence, periconceptual administration may be deleterious to pregnancy outcome. Serum samples were obtained from 8 IVF patients who conceived during the cycle inwhich they had inadvertent luteal phase exposure to GnRH analogues. RESULTS: Elevated serum levels of inhibin A were detected in ongoing pregnancies from 4 weeks' gestation and increased to an initial peak at 9-10 weeks' gestation. Significantly higher levels (P < 0.05) were found in the multiple pregnancies, and nonviable clinical pregnancies had very low levers of inhibin A. Inhibin pro-alpha C was detectable at levels above normal lateluteal values in singleton and multiple pregnancies arising from IVF with fresh embryo transfer. In pregnancies established without corpus luteum activity, frozen-thaw embryo replacement, the levels of pro-alpha C containinginhibins were extremely low, suggesting that the corpus luteum is the major source of the alpha monomer. In pregnancies following inadvertent periconceptual exposure to GnRH analogue, the levels of pro-alpha C were statistically significantly higher in successful pregnancies than in early pregnancyfailures. CONCLUSIONS: The fete-placental unit is confirmed as the major source of inhibin A in early pregnancy, and the initially low levels and very rapid decline in inhibin A in pregnancies with embryonic failure suggest a role forthis glycoprotein as a monitor of early pregnancy viability. The corpus luteum is demonstrated to be the major source of inhibin pro-alpha C in earlypregnancy, and very low levels in patients with peri-implantational exposure are indicative of lytic damage and herald pregnancy failure despite luteal supplementation with progesterone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:40:45