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Titolo:
Outcomes of primary phakic trabeculectomies without versus with 0.5- to 1-minute versus 3- to 5-minute mitomycin C
Autore:
Kim, YY; Sexton, RM; Shin, DH; Kim, CS; Ginde, SA; Ren, JM; Lee, DM; Kupin, TH;
Indirizzi:
Wayne State Univ, Kresge Eye Inst, Detroit, MI 48201 USA Wayne State UnivDetroit MI USA 48201 sge Eye Inst, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Detroit, MI 48201 USA Wayne State Univ DetroitMI USA 48201 niv, Sch Med, Detroit, MI 48201 USA Korea Univ, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 orea Univ, Seoul 136701, South Korea Henry Ford Hosp, Detroit, MI 48202 USA Henry Ford Hosp Detroit MI USA 48202 nry Ford Hosp, Detroit, MI 48202 USA
Titolo Testata:
AMERICAN JOURNAL OF OPHTHALMOLOGY
fascicolo: 6, volume: 126, anno: 1998,
pagine: 755 - 762
SICI:
0002-9394(199812)126:6<755:OOPPTW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAUCOMA FILTRATION SURGERY; ADJUNCTIVE MITOMYCIN; FILTERING SURGERY; REFRACTORY GLAUCOMA; HYPOTONY; 5-FLUOROURACIL; FLUOROURACIL; EYES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, DH WayneUSAate Univ, Kresge Eye Inst, 4717 St Antoine Blvd, Detroit,MI 48201 Wayne State Univ 4717 St Antoine Blvd Detroit MI USA 48201 48201
Citazione:
Y.Y. Kim et al., "Outcomes of primary phakic trabeculectomies without versus with 0.5- to 1-minute versus 3- to 5-minute mitomycin C", AM J OPHTH, 126(6), 1998, pp. 755-762

Abstract

PURPOSE: To compare the intraocular pressure and hypotony outcomes of primary phakic trabeculectomies with no mitomycin C (MMC), shorter MMC, and longer MMC exposure. METHODS: We evaluated primary phakic trabeculectomies with no MMC (36 eyesof 36 patients), 0.5- to 1-minute MMC (50 eyes of 50 patients), and 3- to 5-minute MMC (38 eyes of 38 patients) at the concentration of 0.5 mg/ml. Successful trabeculectomy was defined as an intraocular pressure of 21 mm Hg or less without development of a marked visual acuity loss associated with prolonged hypotony (intraocular pressure < 6 mm Hg over 3 months) and without the need for additional surgery to control intraocular pressure or treatpostoperative complications. RESULTS: The three groups were similar in demographics, preoperative intraocular pressure, and medical dependency. However, the incidence of hypotonyduring the postoperative periods of 3 to 12 months was significantly higher in the 3 to 5-minute MMC group (P < .05, chi-square test). Severe visual acuity loss associated with hypotony was also more frequently found in the 3- to 5-minute MMC group than in the 0.5 to 1-minute (P = .009, chi square test) group or the control group (P = .014, chi-square test). In addition, the success probabilities were significantly different: among the three groups (P = .001, Kaplan-Meier survival analysis with log-rank test) and were the highest in the 0.5 to 1-minute MMC group and the lowest in the 3- to 5-minute MMC group. CONCLUSION: Shorter application (0.5 to 1 minute) of MMC appears to be optimal for the successful outcome of primary phakic trabeculectomy compared with no MMC or longer application of MMC at a concentration of 0.5 mg/ml. (Am J Ophthalmol 1998;126:755-762. (C) 1998 by Elsevier Science Inc. All rights reserved.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:43:38