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Titolo:
Coronary vasodilator reserve is impaired in patients with hypertrophic cardiomyopathy and left ventricular dysfunction
Autore:
Lorenzoni, R; Gistri, R; Cecchi, F; Olivotto, I; Chiriatti, G; Elliott, P; McKenna, WJ; Camici, PG;
Indirizzi:
Hammersmith Hosp, MRC, Ctr Clin Sci, London W12 0NN, England Hammersmith Hosp London England W12 0NN lin Sci, London W12 0NN, England Hammersmith Hosp, Royal Postgrad Med Sch, London W12 0NN, England Hammersmith Hosp London England W12 0NN Med Sch, London W12 0NN, England St George Hosp, Sch Med, Dept Cardiol Sci, London SW17 0RE, England St George Hosp London England SW17 0RE iol Sci, London SW17 0RE, England CNR, Inst Clin Physiol, I-56100 Pisa, Italy CNR Pisa Italy I-56100CNR, Inst Clin Physiol, I-56100 Pisa, Italy
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 6, volume: 136, anno: 1998,
pagine: 972 - 981
SICI:
0002-8703(199812)136:6<972:CVRIII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; POSITRON-EMISSION TOMOGRAPHY; ARTERY DISEASE; N-13 AMMONIA; CHEST PAIN; NONINVASIVE QUANTIFICATION; PERFUSION ABNORMALITIES; SYMPTOMATIC PATIENTS; COMPUTED-TOMOGRAPHY; PATHO-PHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Camici, PG Hammersmith Hosp, MRC, Ctr Clin Sci, Ducane Rd, London W12 0NN,England Hammersmith Hosp Ducane Rd London England W12 0NN 0NN, England
Citazione:
R. Lorenzoni et al., "Coronary vasodilator reserve is impaired in patients with hypertrophic cardiomyopathy and left ventricular dysfunction", AM HEART J, 136(6), 1998, pp. 972-981

Abstract

Background We tested the hypothesis that a reduced delivery of blood to the myocardium is involved in the develop ment of systolic dysfunction of patients with hypertrophic cardiomyopathy (HCM). Methods and Results Eighty-four patients with HCM (62 men, age 43 +/- 12 years) were studied. Left ventricular dimensions and function (fractional shortening) were evaluated by 2-dimensional echocordiography. Myocardial blood flow (MBF) was measured by N-13-ammonia or O-15-water and positron emission tomography at baseline and after dipyridamole; coronary vasodilator reserve (CVR) was calculated as dipyridamole/baseline MBF. Patients with HCM inadvanced New York Heart Association (NYHA) classes had lower dipyridamole MBF (NYHA class I = 1.57 +/- 0.64 vs class II = 1.52 +/- 0.58 vs class III = 0.96 +/- 0.32 mL/min per gram; analysis of variance, P < .05) and CVR (NYHA class I = 1.93 +/- 0.64 vs class II = 1.69 +/- 0.54 vs class III = 1.40 /- 0.43; analysis of variance, P < .05). A positive linear correlation between fractional shortening and dipyridamole MBF was demonstrated (R = 0.23,P < .05), and patients with abnormal fractional shortening had lower dipyridamole MBF (1.07 +/-: 0.43 vs 1.58 +/- 0.62 mL/min per gram, P < .01). Conclusions systolic dysfunction in HCM may be caused by a more severe alteration of the coronary vasodilator capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:11:35