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Titolo:
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
Autore:
Selkoe, DJ;
Indirizzi:
Harvard115iv, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02 Harvard Univ Boston MA USA 02115 , Sch Med, Ctr Neurol Dis, Boston, MA 02
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 11, volume: 8, anno: 1998,
pagine: 447 - 453
SICI:
0962-8924(199811)8:11<447:TCBOBP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; CAENORHABDITIS-ELEGANS; SECRETASE CLEAVAGE; MASS-SPECTROMETRY; SENILE PLAQUES; NT2N CELLS; PEPTIDE; DISTINCT; PATHWAY; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Selkoe, DJ Harvard115iv, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02 Harvard Univ Boston MA USA 02115 Ctr Neurol Dis, Boston, MA 02
Citazione:
D.J. Selkoe, "The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease", TR CELL BIO, 8(11), 1998, pp. 447-453

Abstract

It is a truism of modern biomedical science that the development of therapies expected to slow or arrest the progression of a disease requires as detailed an understanding of its molecular ann cellular pathogenesis as possible. In turn, the cloning of novel gene products implicated in a disease often leads to new insights about fundamental features of protein structure ann function. A particularly compelling example of this beneficial interplay between basic and applied cell biology arises from the exciting recent progress in deciphering Alzheimer's disease (AD). This review discusses the current understanding of the cell biology of two proteins crucial for the pathogenesis of AD, the beta-amyloid precursor protein ann presenilin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:40:39