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Titolo:
HLA class I and class II of the Nivkhi, an indigenous population carrying HTLV-1 in Sakhalin, Far Eastern Russia
Autore:
Lou, H; Li, HC; Kuwayama, M; Yashiki, S; Fujiyoshi, T; Suehara, M; Osame, M; Yamashita, M; Hayami, M; Gurtsevich, V; Ballas, M; Imanishi, T; Sonoda, S;
Indirizzi:
Kagoshima Univ, Fac Med, Dept Virol, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 t Virol, Kagoshima 8908520, Japan Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 l Med 3, Kagoshima 8908520, Japan Kyoto Univ, Inst Virus Res, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 niv, Inst Virus Res, Kyoto 6068397, Japan Russian,Acad Med Sci, Canc Res Ctr, Viral Carcinogenesis Lab, Moscow 115478 Russian Acad Med Sci Moscow Russia 115478 cinogenesis Lab, Moscow 115478 Natl Inst Genet, Ctr Informat Biol, Shizuoka 4110801, Japan Natl Inst Genet Shizuoka Japan 4110801 mat Biol, Shizuoka 4110801, Japan
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 5, volume: 52, anno: 1998,
pagine: 444 - 451
SICI:
0001-2815(199811)52:5<444:HCIACI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLELES; DNA; CARRIERS;
Keywords:
HLA class 1; II alleles and haplotypes; HTLV-1 carriers; Nivkhi natives; phylogenetic tree;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sonoda, S Kagoshima Univ, Fac Med, Dept Virol, Sakuragaoka 8-35-1, Kagoshima 8908520, Kagoshima Univ Sakuragaoka 8-35-1 Kagoshima Japan 8908520 8520,
Citazione:
H. Lou et al., "HLA class I and class II of the Nivkhi, an indigenous population carrying HTLV-1 in Sakhalin, Far Eastern Russia", TISSUE ANTI, 52(5), 1998, pp. 444-451

Abstract

The Nivkhi are a native people isolated in the NogIiki region of Sakhalin,Far East Russia, where our group recently recognized human T-cell lymphomavirus type I(HTLV-I) infection. In order to trace the Nivkhi's ethnic background and the HTLV-I carriers, we investigated HLA class I and II allele types of 53 Nivkhi (including four HTLV-I carriers). Major HLA class I alleles of the Nivkhi were A*24, A*02, B*40, B*48, B*27, B*35 with allele frequencies similar to the Orochon, a native people isolated in Northeast China. Major Nivkhi class II alleles were DRB1*0901, DRB1*1401, DRB1*1201, DRB1*1106 with allele frequencies similar to the Ainu in Hokkaido, Japan, but dissimilar to other Asian Mongoloids, including the general Japanese population. The same HLA class I and II allele frequencies are found in both Nivkhi HTLV-I carriers and the background population. A dendrogram of HLA class I alleles showed that the Nivkhi were closely related to the Orochon and Yakut, and remotely related to the Japanese, Ainu and other Asian Mongoloids. Interestingly, the Nivkhi were intermediately related to the Amerindians (Inuit, Tlingit and Andeans) a relationship closer than to the Japanese and Asian Mongoloids. These results suggested the Nivkhi might be related to some genetic group of Northeast Asian Mongoloids like the Orochon and Yakut, being infected with NTLV-I in the distant past before diverging into the current major Mongoloid ethnic groups.

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Documento generato il 29/09/20 alle ore 21:54:20