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Titolo:
Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals
Autore:
Frossard, PM; Bokhari, AM; Elshahat, YI; Lestringant, GG; John, AM; Hill, SH; Abdulle, AM; Obineche, EN;
Indirizzi:
Al Ain Hosp, Fac Med & Hlth Sci, Dept Pathol, Al Ain, U Arab Emirates Al Ain Hosp Al Ain U Arab Emirates Dept Pathol, Al Ain, U Arab Emirates
Titolo Testata:
SAUDI MEDICAL JOURNAL
fascicolo: 6, volume: 19, anno: 1998,
pagine: 713 - 719
SICI:
0379-5284(199811/12)19:6<713:AEIODD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; GENE I/D POLYMORPHISM; II TYPE-1 RECEPTOR; PLASMA ACE LEVELS; ESSENTIAL-HYPERTENSION; LINKAGE ANALYSIS; MYOCARDIAL-INFARCTION; MOLECULAR-BIOLOGY; BLOOD-PRESSURE; ASSOCIATION;
Keywords:
angiotensin-converting enzyme; cardiovascular diseases; genetics; hypertension; myocardial infarction; polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Frossard, PM AlratesHosp, Fac Med & Hlth Sci, Dept Pathol, POB 17666, Al Ain, U Arab Emi Al Ain Hosp POB 17666 Al Ain U Arab Emirates in, U Arab Emi
Citazione:
P.M. Frossard et al., "Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals", SAUDI MED J, 19(6), 1998, pp. 713-719

Abstract

Objectives: The absence of a 287 base pairs Alu sequence in the angiotensin-converting enzyme gene (D allele) is associated with higher angiotensin converting enzyme levels than its presence (I allele). There is, however, a huge body of conflicting reports that have linked angiotensin-converting enzyme insertion/deletion to hypertension, ischaemic heart disease, myocardial infarction, left ventricular hypertrophy, as well as several other clinical entities. We carried out a retrospective, case-control study of the angiotensin-converting enzyme insertion/deletion dimorphism in relation to circulating angiotensin-converting enzyme activity, as well as to hypertention,ischemic heart disease, myocardial infaction and left ventricular hypertrophy, amongst United Arab Emirates nationals subjects (Emirati). Methods: We investigated a sample population of 285 Emirati comprising groups of controls and of patients with clinical diagnoses of hypertension, ischaemic heart disease, myocardial infaction and left ventricular hypertrophy. Angiotensin-converting enzyme insertion/deletion genotypes were determined by assays based on polymerase chain reaction. Results: The D allele was associated with increased circulating angiotensin-converting enzyme activity, and the angiotensin-converting enzyme insertion/deletion marker accounted for 28% of the variance of the phenomenon determining angiotensin-converting enzyme levels. We found, however, no association between angiotensin-converting enzyme insertion/deletion and clinical diagnoses of hypertension, ischaemic heart disease, myocardial infarction and left ventricular hypertrophy. Conclusion: Although the D allele of the angiotensin converting enzyme insertion/deletion dimorphism tracks with circulating angiotensin-converting enzyme activities in United Arab Emirates nationals, it does not constitute a predictive marker for CVDs in this population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:28:40