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Titolo:
Dysregulation of cardiovascular and neuroendocrine responses to stress in premenstrual dysphoric disorder
Autore:
Girdler, SS; Pedersen, CA; Straneva, PA; Leserman, J; Stanwyck, CL; Benjamin, S; Light, KC;
Indirizzi:
Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Psychol, Chapel Hill, NC 27559 USA Univ N Carolina Chapel Hill NC USA 27559 ychol, Chapel Hill, NC 27559 USA Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC 27599 USA Univ N CarolinaChapel Hill NC USA 27599 Hlth, Chapel Hill, NC 27599 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2, volume: 81, anno: 1998,
pagine: 163 - 178
SICI:
0165-1781(19981116)81:2<163:DOCANR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; MENSTRUAL-CYCLE PHASE; URINARY NOREPINEPHRINE; PROLACTIN RESPONSES; PLASMA-CORTISOL; MOOD DISORDERS; SEXUAL ABUSE; SYNDROME PMS; WOMEN; HORMONE;
Keywords:
menstrual cycle; sexual abuse; cortisol; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Girdler, SS Univapelarolina, Sch Med, Dept Psychiat, Campus Box 7175,Med Res Bldg A, Ch Univ N Carolina Campus Box 7175,Med Res Bldg A Chapel Hill NCUSA 27599
Citazione:
S.S. Girdler et al., "Dysregulation of cardiovascular and neuroendocrine responses to stress in premenstrual dysphoric disorder", PSYCHIAT R, 81(2), 1998, pp. 163-178

Abstract

Twelve women with prospectively confirmed premenstrual dysphoric disorder (PMDD or PDD) were compared with 12 healthy control subjects for cardiovascular and neuroendocrine responses to speech and mental arithmetic (Paced Auditory Serial Addition Task) stressors during both the follicular and luteal phases of the menstrual cycle. Structured clinical interview was used to assess psychiatric and abuse histories, and standardized questionnaires were administered to assess current life stress. Results revealed that PMDD women had significantly lower stroke volume, cardiac output and cortisol levels but significantly elevated norepinephrine and total peripheral resistance at rest and also during mental stressors compared with control subjects. These effects were evident in both cycle phases. Significantly more women with PMDD had histories of sexual abuse, and they also reported greater current life stress than control subjects. Consistent with a history of trauma,the PMDD women exhibited significantly greater ratios of norepinephrine tocortisol at rest and during stress. These results are interpreted as reflecting dysregulation of the stress response and may be related to histories of severe and/or chronic exposure to stress for a subgroup of PMDD women. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:03:49