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Titolo:
Peptides related to FKBP 39-45 loop possess immunostimulative potency
Autore:
Siemion, IZ; Strug, T; Wieczorek, Z;
Indirizzi:
Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50383 Fac Chem, PL-50383 Wroclaw, Poland Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland Polish Acad Sci Wroclaw Poland PL-53114 herapy, PL-53114 Wroclaw, Poland
Titolo Testata:
PEPTIDES
fascicolo: 9, volume: 19, anno: 1998,
pagine: 1479 - 1487
SICI:
0196-9781(1998)19:9<1479:PRTF3L>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; IMMUNOSUPPRESSANT FK506; PROLYL ISOMERASE; INTERLEUKIN-1; IMMUNOPHILIN; CYCLOPHILIN; CALCINEURIN; COMPLEXES; ACTIVATION; ASSAY;
Keywords:
FKBP; thymopoietin; thymopentin; thymopoietin-like sequences; immunostimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Siemion, IZ Univ Wroclaw, Fac Chem, Joliot Curie 14, PL-50383 Wroclaw, Poland Univ Wroclaw Joliot Curie 14 Wroclaw Poland PL-50383 , Poland
Citazione:
I.Z. Siemion et al., "Peptides related to FKBP 39-45 loop possess immunostimulative potency", PEPTIDES, 19(9), 1998, pp. 1479-1487

Abstract

151 Taking into account the sequential homology existing between thymopoietin II, the DNA-binding domain of p53 protein and FKBP (FK-506 binding protein), a series of fragments of human and bovine FKBP containing a fragment Ser(39)-Pro(45) were synthesized. In the humoral in vitro test all the peptides act as stimulators. Whereas in the in vivo test peptides derived from bovine FKBP show an immunostimulative and those from human FKBP an immunosuppressive activity. However, after blocking the Asp residue by a Bzl group the peptide V appears to be an immunostimulator. The data obtained suggest that these peptides can influence the immune system by blocking the FKBP receptor. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:11:01