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Titolo:
Immunodominant peptide epitopes of allergen, Asp f 1 from the fungus Aspergillus fumigatus
Autore:
Kurup, VP; Banerjee, B; Murali, PS; Greenberger, PA; Krishnan, M; Hari, V; Fink, JN;
Indirizzi:
Med Coll Wisconsin, Dept Med, Div Allergy Immunol, Milwaukee, WI 53226 USAMed Coll Wisconsin Milwaukee WI USA 53226 mmunol, Milwaukee, WI 53226 USA Dept Vet Affairs Med Ctr, Milwaukee, WI USA Dept Vet Affairs Med Ctr Milwaukee WI USA irs Med Ctr, Milwaukee, WI USA Northwestern Univ, Sch Med, Div Allergy Immunol, Chicago, IL USA Northwestern Univ Chicago IL USA d, Div Allergy Immunol, Chicago, IL USA Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA Wayne State Univ Detroit MI USA 48202 ept Biol Sci, Detroit, MI 48202 USA
Titolo Testata:
PEPTIDES
fascicolo: 9, volume: 19, anno: 1998,
pagine: 1469 - 1477
SICI:
0196-9781(1998)19:9<1469:IPEOAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL EPITOPES; BRONCHOPULMONARY ASPERGILLOSIS; B-CELL; POLLEN ALLERGEN; IGE-BINDING; CYSTIC-FIBROSIS; ANTIGEN; PROTEIN; IDENTIFICATION; ANTIBODIES;
Keywords:
Aspergillus fumigatus; allergic bronchopulmonary aspergillosis; B-cell epitope; T-cell epitope;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kurup, VP Vet Adm Med Ctr, Res Serv 151I, 5000 W Natl Ave, Milwaukee, WI 53295 USA Vet Adm Med Ctr 5000 W Natl Ave Milwaukee WI USA 53295 53295 USA
Citazione:
V.P. Kurup et al., "Immunodominant peptide epitopes of allergen, Asp f 1 from the fungus Aspergillus fumigatus", PEPTIDES, 19(9), 1998, pp. 1469-1477

Abstract

Aspergillus fumigatus ribotoxin Asp f 1 is a major allergen with IgE binding activity to serum of a majority of patients with allergic bronchopulmonary aspergillosis (ABPA). The IgE binding epitopes or the T-cell stimulatorypeptides of this molecule have not been studied. In the present investigation, we have synthesized linear decapeptides spanning the whole molecule ofAsp f 1 and analyzed their IgE binding properties. We have also synthesized peptides based on their possible T-cell stimulatory properties and studied the stimulation of peripheral blood mononuclear cells from ABPA patients and normal controls. Several peptides demonstrated distinct IgE antibody binding response against sera from ABPA patients and proliferative response against peripheral blood mononuclear cells from the patients. From the results, it can be concluded that the carboxy-terminal region of Asp f 1 representing amino acid residues 115-149 involved in both humoral and cell mediated immunoresponses in ABPA. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 12:53:52