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Titolo:
Procalcitonin is a marker of severity of renal lesions in pyelonephritis
Autore:
Benador, N; Siegrist, CA; Gendrel, D; Greder, C; Benador, D; Assicot, M; Bohuon, C; Girardin, E;
Indirizzi:
Childrens Hosp, Dept Pediat, Geneva, Switzerland Childrens Hosp Geneva Switzerland osp, Dept Pediat, Geneva, Switzerland Hop St Vincent de Paul, Dept Pediat, F-75674 Paris, France Hop St Vincent de Paul Paris France F-75674 ediat, F-75674 Paris, France Hop St Vincent de Paul, Microbiol Lab, F-75674 Paris, France Hop St Vincent de Paul Paris France F-75674 l Lab, F-75674 Paris, France Inst Gustave Roussy, Villejuif, France Inst Gustave Roussy Villejuif France Gustave Roussy, Villejuif, France
Titolo Testata:
PEDIATRICS
fascicolo: 6, volume: 102, anno: 1998,
pagine: 1422 - 1425
SICI:
0031-4005(199812)102:6<1422:PIAMOS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM PROCALCITONIN; CHILDREN; SCINTIGRAPHY; INFECTIONS; BACTERIAL; CHILDHOOD; SEPSIS; FOLLOW;
Keywords:
pyelonephritis; UTI; procalcitonin; C-reactive protein; DMSA scintigraphy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Benador, N Univ Calif San Diego, Dept Pediat, 9500 Gilman Dr, La Jolla, CA92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 3 USA
Citazione:
N. Benador et al., "Procalcitonin is a marker of severity of renal lesions in pyelonephritis", PEDIATRICS, 102(6), 1998, pp. 1422-1425

Abstract

Objective, In an attempt to differentiate acute pyelonephritis from lower urinary tract infection (UTI), we measured serum procalcitonin levels, a recently described marker of infection. We compared it with other commonly used inflammatory markers and evaluated its ability to predict renal involvement as assessed by dimercaptosuccinic acid (DMSA) scintigraphy. Methods. Serum C-reactive protein, leukocyte counts, and procalcitonin levels were measured in 80 children, 1 month to 16 years of age, admitted for suspected pyelonephritis. Renal involvement was assessed by Te-99m-DMSA scintigraphy in the first 5 days after admission. The examination was repeatedat least 3 months later if the first result was abnormal. Results. In lower UTI, the mean procalcitonin (PCT) was 0.38 mu g/L +/- 0.19 compared with 5.37 mu g/L +/- 1.9 in pyelonephritis. In these two groups, respectively, leukocyte counts were 10939/mm(3) +/- 834 and 17429/mm(3) +/- 994, and C-reactive protein (CRP) levels were 30.3 mg/L +/- 7.6 and 120.8 mg/L +/- 8.9. When inflammatory markers were correlated to the severity of the renal lesion as ranked by DMSA scintigraphy, we found a highly significant correlation with plasma levels of PCT, but borderline significance with CRP and none with leukocyte counts. Patients without vesicoureteral reflux. had a mean PCT of 5.16 mu g/L +/- 2.33, which was not significantly different from that in patients with reflux who had a mean PCT of 5.76 mu g/L /- 3.49. For the prediction of renal lesions at admission, CRP had a sensitivity of 100% and a specificity of 26.1%. The sensitivity and specificity of PCT were 70.3% and 82.6%, respectively. Conclusion, We conclude that serum PCT levels were increased significantlyin children with febrile UTI when renal parenchymal involvement (assessed by DMSA scintigraphy) was present and allowed for prediction of patients atrisk of severe renal lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:22:08