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Antioxidant nutrient intake and diabetic retinopathy - The San Luis ValleyDiabetes Study
Mayer-Davis, EJ; Bell, RA; Reboussin, BA; Rushing, J; Marshall, JA; Hamman, RF;
Univ8S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 2920 Univ S Carolina Columbia SC USA 29208 demiol & Biostat, Columbia, SC 2920 Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27109 USAWake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Univ Colorado, Sch Med, Dept Prevent Med & Biometr, Denver, CO USA Univ Colorado Denver CO USA , Dept Prevent Med & Biometr, Denver, CO USA
Titolo Testata:
fascicolo: 12, volume: 105, anno: 1998,
pagine: 2264 - 2270
Tipo documento:
Settore Disciplinare:
Clinical Medicine
Life Sciences
Indirizzi per estratti:
Indirizzo: Mayer-Davis, EJ Univ8S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 2920 Univ S Carolina Columbia SC USA 29208 , Columbia, SC 2920
E.J. Mayer-Davis et al., "Antioxidant nutrient intake and diabetic retinopathy - The San Luis ValleyDiabetes Study", OPHTHALMOL, 105(12), 1998, pp. 2264-2270


Objective: Diabetic retinopathy (DR) is a major cause of visual impairmentand blindness in adults. Antioxidant nutrients, such as vitamins C and E and beta-carotene, may be protective of some eye disorders, such as cataractand age-related macular degeneration, but a relationship between these nutrients and DR has yet to be defined. The purpose of this study was to examine the relation between dietary and supplement intakes of vitamins C, E, and beta-carotene and the risk of DR. Design: Both cross-sectional and longitudinal data were collected from participants in the San Luis Valley Diabetes Study, including non-Hispanic white and Hispanic adults in southern Colorado. Participants: A total of 387 participants with type 2 diabetes completed at least 1 complete retinal examination and 24-hour dietary recall (including vitamin supplement use). Main Outcome Measures: Type 2 diabetes was defined according to World Health Organization criteria. DR was assessed by retinal photographs, using theAirlie House criteria to classify DR as none, background, preproliferative, or proliferative. Data for both eyes, from up to three clinic visits per participant, were used for analysis. Ordinal logistic regression analysis was used, taking advantage of multiple clinic visits by individual participants and observations from both eyes, to assess the risk for increased DR severity over time as a function of changes in intake of vitamin C, vitamin E, and beta-carotene. Six categories of intake for each nutrient (first to fourth quintiles and ninth and tenth deciles) were considered to ascertain any potential threshold effect. Analyses accounted for age, duration of diabetes, insulin use, ethnicity, glycated hemoglobin, hypertension, gender, and caloric intake. Results: An increase over lime in vitamin C intake from the first to ninthdeciles was associated with a risk for increased severity of DR (odds ratio = 2.21, P = 0.01), although excess risk was not observed for the tenth decile or the second through fourth quintiles compared to the first quintile. Increased intake of vitamin E was associated with increased severity of DRamong those not taking insulin (odds ratios = 2.69, 2.59, 3.33, 5.65, 3.79; P < 0.02, for an increase over time from the first to the second through fourth quintiles and ninth and tenth deciles, respectively). Among those taking insulin, increased intake of beta-carotene was associated with a risk for severity of DR (odds ratio = 3.31, P = 0.003, and 2.99, P = 0.002, respectively, for the ninth and tenth deciles compared to the first quintile). Conclusions: No protective effect was observed between antioxidant nutrients and DR. Depending on insulin use, there appeared to be a potential for deleterious effects of nutrient antioxidants. Further research is needed to confirm associations of nutrient antioxidant intake and DR.

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Documento generato il 28/11/20 alle ore 09:27:06