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Titolo:
Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr
Autore:
Dieckmann, T; Withers-Ward, ES; Jarosinski, MA; Liu, CF; Chen, ISY; Feigon, J;
Indirizzi:
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA Univ Calif LosAngeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, AIDS Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Amgen Inc, Boulder, CO 80301 USA Amgen Inc Boulder CO USA 80301Amgen Inc, Boulder, CO 80301 USA Dept DNA & Peptide Chem, Boulder, CO 80301 USA Dept DNA & Peptide Chem Boulder CO USA 80301 Chem, Boulder, CO 80301 USA
Titolo Testata:
NATURE STRUCTURAL BIOLOGY
fascicolo: 12, volume: 5, anno: 1998,
pagine: 1042 - 1047
SICI:
1072-8368(199812)5:12<1042:SOAHDR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY STRUCTURE PREDICTION; CELL-CYCLE; NMR-SPECTROSCOPY; H-1-NMR SPECTRA; SEQUENCE; ARRESTS; PROGRAM; PHASE; G(2);
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Feigon, J Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 s, CA 90095 USA
Citazione:
T. Dieckmann et al., "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr", NAT ST BIOL, 5(12), 1998, pp. 1042-1047

Abstract

The HIV-1 protein Vpr is critical for a number of viral functions including a unique ability to arrest T-cells at a G2/M checkpoint and induce subsequent apoptosis. It has been shown to interact specifically with the second UBA (ubiquitin associated) domain found in the DNA repair protein HHR23A, ahighly evolutionarily conserved protein. This domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases, The three dimensional structure of the UBA domain, determined by NMR spectroscopy, is presented. The protein domain forms a compact three-helix bundle. One side of the protein has a hydrophobic surface that is the most likely Vpr target site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:12:45