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Titolo:
Posttranscriptional control of gene expression in yeast
Autore:
McCarthy, JEG;
Indirizzi:
UnivlManchester, Inst Sci & Technol, Dept Biomol Sci, Posttranscript Contro Univ Manchester Manchester Lancs England M60 1QD i, Posttranscript Contro
Titolo Testata:
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
fascicolo: 4, volume: 62, anno: 1998,
pagine: 1492 -
SICI:
1092-2172(199812)62:4<1492:PCOGEI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAP-BINDING-PROTEIN; MESSENGER-RNA DECAY; DOUBLE-STRANDED-RNA; EUKARYOTIC INITIATION FACTOR-4E; IMPORTANT AROMATIC-COMPOUNDS; GCN4 TRANSLATIONAL CONTROL; CHAIN RELEASE FACTORS; OPEN READING FRAME; SACCHAROMYCES-CEREVISIAE GENE; TERMINATION SIGNAL DATABASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
650
Recensione:
Indirizzi per estratti:
Indirizzo: McCarthy, JEG UnivlManchester, Inst Sci & Technol, Dept Biomol Sci, Posttranscript Contro Univ Manchester Manchester Lancs England M60 1QD ipt Contro
Citazione:
J.E.G. McCarthy, "Posttranscriptional control of gene expression in yeast", MICRO M B R, 62(4), 1998, pp. 1492

Abstract

Studies of the budding yeast Saccharomyces cerevisiae have greatly advanced out understanding of the posttranscriptional steps of eukaryotic gene expression. Given the wide range of experimental tools applicable to S. cerevisiae and the recent determination of its complete genomic sequence, many ofthe key challenges of the posttranscriptional control field can be tackledparticularly effectively by using this organism. This article reviews the current knowledge of the cellular components and mechanisms related to translation and mRNA decay, with the emphasis on the molecular basis for rate control and gene regulation. Recent progress in characterizing translation factors and their protein-protein and RNA-protein interactions has been rapid. Against the background of a growing body of structural information, the review discusses the thermodynamic and kinetic principles that govern the translation process. As in prokaryotic systems, translational initiation is a key point of control. Modulation of the activities of translational initiation factors imposes global regulation in the cell, while structural features of particular 5' untranslated regions, such as upstream open reading frames and effector binding sites, allow for gene-specific regulation. Recentdata have revealed many new details of the molecular mechanisms involved while providing insight into the functional overlaps and molecular networking that are apparently a key feature of evolving cellular systems. An overall picture of the mechanisms governing mRNA decay has only very recently begun to develop. The latest work has revealed new information about the mRNA decay pathways, the components of the mRNA degradation machinery, and the way in which these might relate to the translation apparatus. Overall, majorchallenges still to be addressed include the task of relating principles of posttranscriptional control to cellular compartmentalization and polysomestructure and the role of molecular channeling in these highly complex expression systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 07:11:55