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Titolo:
Regional distribution of manganese found in the brain after injection of asingle dose of manganese-based contrast agents
Autore:
Gallez, B; Baudelet, C; Geurts, M;
Indirizzi:
UnivmCatholique Louvain, Lab Med Chem & Radiopharm, B-1200 Brussels, Belgiu Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgiu
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 10, volume: 16, anno: 1998,
pagine: 1211 - 1215
SICI:
0730-725X(199812)16:10<1211:RDOMFI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANGAFODIPIR TRISODIUM; MN-DPDP; RATS; TOXICITY; ACCUMULATION; CHLORIDE; EXPOSURE; METALS;
Keywords:
manganese; brain; toxicity; contrast agent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gallez, B Univ00atholique Louvain, Lab Med Chem & Radiopharm, Ave Mounier 73-40, B-12 Univ Catholique Louvain Ave Mounier 73-40 Brussels Belgium B-1200
Citazione:
B. Gallez et al., "Regional distribution of manganese found in the brain after injection of asingle dose of manganese-based contrast agents", MAGN RES IM, 16(10), 1998, pp. 1211-1215

Abstract

Manganese (Mn) complexes are unstable and dissociate in vivo. Because of the release of this metal, there exists some concern about the potential long-term neurotoxicity associated with the use of Mn-based contrast agents. This latter problem arises because manganese is known to accumulate in specific regions of the brain of people intoxicated by this metal. It was previously demonstrated that Mn can accumulate in the mice brain after administration of 5 mu mol/kg of MnCl2, Mn-diethylenetriaminepentaacetate (Mn-DTPA), or Mn-dipyridoxal diphosphate (Mn-DPDP), In order to better characterize the behavior of Mn complexes after administration, this study assesses the regional distribution of Mn in the brain after i.v. injection of a single dose of MnCl2 or Mn-DTPA. Male Wistar rats received an i.v. injection of 5 mu mol/kg of Mn-54 as MnCl2 or Mn-DTPA, The rats were killed at one and two weeks post exposure. The distribution of the radioactivity in the slices was monitored by autoradiography. For both MnCl2 or Mn-DTPA, we observed that the radioactivity was dispersed in the entire brain, but the radioactivity was higher in several regions. No difference was observed between MnCl2 or Mn-DTPA in the regional distribution of Mn, and no difference was observed between the two times of exposure (1 week or 2 weeks). The uptake of Mn was minimal in corpus callosum, Maximal Mn concentration was observed in the hippocampal region, thalamus, colliculi, amygdala, olfactory nuclei, and cerebellum. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:34:12