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Titolo:
BASAL GANGLIA CHOLINE LEVELS IN DEPRESSION AND RESPONSE TO FLUOXETINETREATMENT - AN IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY
Autore:
RENSHAW PF; LAFER B; BABB SM; FAVA M; STOLL AL; CHRISTENSEN JD; MOORE CM; YURGELUNTODD DA; BONELLO CM; PILLAY SS; ROTHSCHILD AJ; NIERENBERG AA; ROSENBAUM JF; BRUCE BM;
Indirizzi:
MCLEAN HOSP,BRAIN IMAGING CTR,115 MILL ST BELMONT MA 02178 MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT BOSTON MA 02114 BRIGHAM & WOMENS HOSP,PSYCHOPHARMACOL UNIT BOSTON MA 00000 MCLEAN HOSP,AFFECT DISORDERS PROGRAM BELMONT MA 02178 HARVARD UNIV,CONSOLIDATED DEPT PSYCHIAT BOSTON MA 02115
Titolo Testata:
Biological psychiatry
fascicolo: 8, volume: 41, anno: 1997,
pagine: 837 - 843
SICI:
0006-3223(1997)41:8<837:BGCLID>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN INVIVO; SIGNAL TRANSDUCTION; METABOLITES; MANIA; HYPOTHESIS; NEURONS; SPECTRA; NUCLEI; RAT;
Keywords:
MAJOR DEPRESSION; FLUOXETINE; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETIC RESONANCE IMAGING; CHOLINE; BASAL GANGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Renshaw et al., "BASAL GANGLIA CHOLINE LEVELS IN DEPRESSION AND RESPONSE TO FLUOXETINETREATMENT - AN IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY", Biological psychiatry, 41(8), 1997, pp. 837-843

Abstract

We have investigated proton magnetic resonance spectra of the basal ganglia in 41 medication-free outpatients with major depression, prior to starting an 8-week standardized trial of open-label fluoxetine, and22 matched comparison subjects. Upon completing the trial, depressed subjects were classified as treatment responders (n = 18) or nonresponders (n = 23), based on changes in the Hamilton Depression Rating Scale. Depressed subjects had a lower area ratio of the choline resonance to the creatine resonance (Cho/Cr) than comparison subjects. This statistically significant difference between the depressed subjects and comparison subjects was more pronounced in the treatment responders thanin the nonresponders. There were no differences in the relative volumes of gray matter or white matter in the voxel used for proton spectroscopy in depressed subjects relative to comparison subjects. These results are consistent with an alteration in the metabolism of cytosolic choline compounds in the basal ganglia of depressed subjects and, in particular, those who are responsive to fluoxetine. (C) 1997 Society ofBiological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:18:51