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Titolo:
Piroxicam therapy: A double blind, randomized, multicenter study comparing2 versus 4 week treatment in patients with painful knee osteoarthritis with effusion
Autore:
Ravaud, P; Auleley, GR; Ayral, X; Marre, JP; Amor, B;
Indirizzi:
Hop Cochin, Rhumatol Clin, F-75674 Paris, France Hop Cochin Paris FranceF-75674 in, Rhumatol Clin, F-75674 Paris, France Hop La Pitie Salpetriere, Serv Rhumatol, Paris, France Hop La Pitie Salpetriere Paris France ere, Serv Rhumatol, Paris, France
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 12, volume: 25, anno: 1998,
pagine: 2425 - 2431
SICI:
0315-162X(199812)25:12<2425:PTADBR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; OSTEO-ARTHRITIS; PLACEBO; JOINT; INFLAMMATION; NAPROXEN; EFFICACY; SAFETY; HIP;
Keywords:
knee osteoarthritis; joint effusion; clinical trial; nonsteroidal antiinflammatory drug; piroxicam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ravaud, P CareF-75014gados M, Hop Cochin, Rhumatol Clin, 27 Rue Faubourg St Jacques, Care of Dougados M 27 Rue Faubourg St Jacques Paris France F-75014
Citazione:
P. Ravaud et al., "Piroxicam therapy: A double blind, randomized, multicenter study comparing2 versus 4 week treatment in patients with painful knee osteoarthritis with effusion", J RHEUMATOL, 25(12), 1998, pp. 2425-2431

Abstract

Objective, To compare the efficacy and safety of piroxicam 20 mg once a day for 14 or 28 days in patients with knee osteoarthritis (OA) and synovial effusion. Methods, We conducted a multicenter, randomized, double blind study in 1905 outpatients. Efficacy was assessed by changes in synovial effusion, pain on a 100 mm visual analog scale (VAS), and impairment using Lequesne's functional index. Patients were classified at Day 28 as improved (defined as VAS and Lequesne index decrease of at least 30% from Day 14), worsened (defined as VAS and Lequesne index increase of at least 30% from Day 14), or unchanged, Safety was assessed on the basis of adverse events reported by the patients. Results, After 14 days, changes in pain, synovial effusion, and functionalimpairment significantly decreased from baseline within each group (p < 0.001, respectively), but did not differ between the groups. Between 14 and 28 days, outcome measure changes were significantly better in the 28 day group, p = 0.01, 0.0001, and 0.0001, respectively. In the 28 day and 14 day groups, improvement with regard to pain was observed for 339 (52.4%) and 280 (29.4%) patients, respectively, (p < 0.0001), and with regard to functionalimpairment for 298 (31.5%) and 233 (24.3%) patients (p < 0.0001). Adverse events accounted for 7.5 and 6.7% of withdrawals in the 28 day and 14 day groups, respectively. Conclusion. When administration of piroxicam 20 mg is prolonged to 28 days, continuing benefit is observed for some patients with knee OA with painful synovial effusion without a significant difference in safety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:14:52