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Titolo:
Serum testosterone levels are not elevated in patients with ankylosing spondylitis
Autore:
Giltay, EJ; Popp-Snijders, C; van Schaardenburg, D; Dekker-Saeys, BJ; Gooren, LJG; Dijkmans, BAC;
Indirizzi:
Freeodniv Amsterdam Hosp, Dept Endocrinol, Div Androl, Inst Endocrinol Repr Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB ndocrinol Repr Free Univ Amsterdam Hosp, Dept Rheumatol, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Jan Van Breemen Inst, Dept Rheumatol, Amsterdam, Netherlands Jan Van Breemen Inst Amsterdam Netherlands atol, Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 12, volume: 25, anno: 1998,
pagine: 2389 - 2394
SICI:
0315-162X(199812)25:12<2389:STLANE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; HORMONE-BINDING GLOBULIN; MIDDLE-AGED MEN; RHEUMATOID-ARTHRITIS; SEX-HORMONES; DISEASE; MALES; DEHYDROEPIANDROSTERONE; ANDROGENS; STEROIDS;
Keywords:
testosterone; sex hormones; ankylosing spondylitis; phenylbutazone; radioimmunoassay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Gooren, LJG Freeodniv Amsterdam Hosp, Dept Endocrinol, Div Androl, Inst Endocrinol Repr Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay et al., "Serum testosterone levels are not elevated in patients with ankylosing spondylitis", J RHEUMATOL, 25(12), 1998, pp. 2389-2394

Abstract

Objective. Studies in patients with ankylosing spondylitis (AS) describe slightly elevated serum testosterone levels, but these studies were not properly controlled for possible confounders. Methods. In a case-control study serum levels of sex steroids, luteinizinghormone, and sex hormone binding globulin (SHGB) were measured in patientswith AS and in age and sex matched controls. The body mass index, smoking status, use of alcohol, and fat intake were recorded. Results. Testosterone levels measured in serum extracts did not differ in 50 male patients with AS compared to controls (mean +/- SD 16 +/- 4 vs 15 +/- 5 nmol/l, respectively; p = 0.54). In unextracted serum, however, male patients showed elevated testosterone (p < 0.001) and dehydroepiandrosteronesulfate levels (p = 0.003), even after controlling for confounders (p < 0.001). One of 10 female patients had an elevated testosterone level in unextracted serum, The 17 male users and one of the 2 female users of phenylbutazone had the highest testosterone levels in unextracted serum, and all showed a significant decline after extraction. Serum levels of other sex steroids, luteinizing hormone, and SHGB did not differ significantly between patients and controls. Conclusion. Serum testosterone levels are not elevated in male patients with AS. Spuriously elevated testosterone levels in unextracted serum might be related to the use of phenylbutazone in our patient sample.

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Documento generato il 03/12/20 alle ore 14:49:48