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Titolo:
CD4(+) T cell repertoire on the epsilon subunit of muscle acetylcholine receptor in myasthenia gravis
Autore:
Wang, ZY; Okita, DK; Howard, JF; Conti-Fine, BM;
Indirizzi:
Univ Minnesota, Dept Biochem, Twin Cities, MN USA Univ Minnesota Twin Cities MN USA ota, Dept Biochem, Twin Cities, MN USA Univ Minnesota, Dept Pharmacol, Twin Cities, MN USA Univ Minnesota Twin Cities MN USA a, Dept Pharmacol, Twin Cities, MN USA Univ N Carolina, Sch Med, Dept Neurol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 eurol, Chapel Hill, NC 27599 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 91, anno: 1998,
pagine: 33 - 42
SICI:
0165-5728(19981102)91:1-2<33:CTCROT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITOPE REPERTOIRE; SYNTHETIC PEPTIDES; GAMMA-SUBUNIT; ALPHA-SUBUNIT; EXTRAOCULAR-MUSCLE; SEQUENCE SEGMENTS; IMMUNE-RESPONSE; RAT MUSCLE; CLASS-II; IDENTIFICATION;
Keywords:
myasthenia gravis; acetylcholine receptor; T epitope repertoire; autoimmune diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ Minnesota, Dept Biochem, 1479 Gortner Ave, St Paul, MN55108 USA Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 08 USA
Citazione:
Z.Y. Wang et al., "CD4(+) T cell repertoire on the epsilon subunit of muscle acetylcholine receptor in myasthenia gravis", J NEUROIMM, 91(1-2), 1998, pp. 33-42

Abstract

We have identified sequence regions of the human muscle acetylcholine receptor epsilon subunit recognized by CD4(+) T cells from myasthenia gravis patients. We tested the proliferative response in vitro of blood CD4(+) cellsfrom 18 myasthenic patients and 5 controls, to individual overlapping synthetic peptides spanning the epsilon subunit sequence. All patients recognized a complex epitope repertoire. The peptides recognized by the CD4(+) cells included sequence regions of the epsilon subunit that were diverged as compared to the homologous sequences of the other receptor subunits. Recognition of epitopes formed by sequence regions unique to the epsilon subunit suggests a direct role of this subunit in sensitizing the CD4(+) cells. Several epsilon subunit peptides were recognized by many patients. Thus the epsilon subunit, like other acetylcholine receptor subunits, forms 'universal' CD4(+) epitopes. The healthy subjects recognized some epsilon subunit peptides sporadically and at a low level. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/12/20 alle ore 00:01:09