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Titolo:
The enzymatic synthesis of isotopically labelled penicillin Ns with isopenicillin N synthase
Autore:
Baldwin, JE; Adlington, RM; Crouch, NP; Pereira, IAC;
Indirizzi:
Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England Univ Oxford Oxford England OX1 3QY Perrins Lab, Oxford OX1 3QY, England Univ Oxford, Oxford Ctr Mol Sci, Oxford OX1 3QY, England Univ Oxford Oxford England OX1 3QY Ctr Mol Sci, Oxford OX1 3QY, England
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 12, volume: 41, anno: 1998,
pagine: 1145 - 1163
SICI:
0362-4803(199812)41:12<1145:TESOIL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEPHALOSPORIN-C BIOSYNTHESIS; DEACETOXYCEPHALOSPORIN-C; BETA-LACTAM; RING EXPANSION; CONVERSION; ACREMONIUM; PURIFICATION; SPECIFICITY; SYNTHETASE; PATHWAY;
Keywords:
preparation; isotopically; labelled; penicillin Ns;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Baldwin, JE Univ Oxford, Dyson Perrins Lab, S Parks Rd, Oxford OX1 3QY, England Univ Oxford S Parks Rd Oxford England OX1 3QY X1 3QY, England
Citazione:
J.E. Baldwin et al., "The enzymatic synthesis of isotopically labelled penicillin Ns with isopenicillin N synthase", J LABEL C R, 41(12), 1998, pp. 1145-1163

Abstract

The preparation of isotopically labelled penicilllin Ns using a chemico-enzymatic approach is described. This route involves the chemical synthesis of variously labelled (D) under bar,(L) under bar,(D) under bar,-aminoadipoyl-cysteinyl-valine tripeptides via well established facile protocols and concludes with the conversion of these tripeptides directly into penicillin Ns by the action of recombinant isopenicillin N synthase. Milligram quantities of isotopically labelled penicillin Ns, which would otherwise represent very challenging and expensive synthetic targets, are readily accessible from this route.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:28:19