Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Brain opioid receptor measurements by positron emission tomography in normal cycling women: Relationship to luteinizing hormone pulsatility and gonadal steroid hormones
Autore:
Smith, YR; Zubieta, JK; del Carmen, MG; Dannals, RF; Ravert, HT; Zacur, HA; Frost, JJ;
Indirizzi:
Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USAJohns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA Johns Hopkins Med Inst, Dept Gynecol & Obstet, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 et, Baltimore, MD 21287 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 12, volume: 83, anno: 1998,
pagine: 4498 - 4505
SICI:
0021-972X(199812)83:12<4498:BORMBP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREOPTIC AREA; MESSENGER-RIBONUCLEIC-ACID; GONADOTROPIN-RELEASING HORMONE; C-11 CARFENTANIL BINDING; FEMALE GUINEA-PIG; BETA-ENDORPHIN; ESTROGEN-RECEPTOR; OPIATE RECEPTORS; POSTMENOPAUSAL WOMEN; MENSTRUAL-CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, JJ Johns-130,ins Med Inst, Dept Radiol, Div Nucl Med, 600 N Wolfe St,Nelson B1 Johns Hopkins Med Inst 600 N Wolfe St,Nelson B1-130 Baltimore MD USA 21287
Citazione:
Y.R. Smith et al., "Brain opioid receptor measurements by positron emission tomography in normal cycling women: Relationship to luteinizing hormone pulsatility and gonadal steroid hormones", J CLIN END, 83(12), 1998, pp. 4498-4505

Abstract

The regulation of central mu-opioid receptors in women during the menstrual cycle was explored with positron emission tomography and the selective radiotracer [C-11]carfentanil. Ten healthy women were studied twice, during their follicular and luteal phases. Plasma concentrations of estradiol, progesterone, testosterone, and beta-endorphin mere determined immediately before scanning. LH pulsatility was measured over the 9 h preceding each of thetwo positron emission tomography scans. No significant differences in the binding potential of mu-opioid receptors (binding capacity/K-d) were observed between phases of the menstrual cycle. However, significant negative correlations were observed between circulating levels of estradiol during the follicular phase and mu-receptor binding measures in the amygdala and hypothalamus, two regions thought to be involved in the regulation of GnRH pulsatility. LH pulse amplitude was positively correlated with mu binding in theamygdala, whereas LH pulse number was negatively correlated with binding in this same region. No significant associations were noted between LH pulsemeasures and the hypothalamus for this sample. These results suggest that amygdalar mu-opioid receptors exert a modulatory effect on GnRH pulsatility, and that circulating levels of estradiol also regulate central mu-opioid function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:23:31