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Titolo:
Adrenocorticotropin and cortisol hyperresponsiveness to hexarelin in patients with Cushing's disease bearing a pituitary microadenoma, but not in those with macroadenoma
Autore:
Arvat, E; Giordano, R; Ramunni, J; Arnaldi, G; Colao, A; Deghenghi, R; Lombardi, G; Mantero, F; Camanni, F; Ghigo, E;
Indirizzi:
Univ Turin, Div Endocrinol, Ancona, Italy Univ Turin Ancona ItalyUniv Turin, Div Endocrinol, Ancona, Italy Europeptides, Argenteuil, France Europeptides Argenteuil FranceEuropeptides, Argenteuil, France
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 12, volume: 83, anno: 1998,
pagine: 4207 - 4211
SICI:
0021-972X(199812)83:12<4207:AACHTH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; GROWTH-HORMONE; GH SECRETAGOGUE; SECRETION; GHRP-6; ACTH; RECEPTOR; ABSENCE; HUMANS; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ghigo, E Osped Molinette, Div Endocrinol, Cso Dogliotti 14, I-10126 Turin,Italy Osped Molinette Cso Dogliotti 14 Turin Italy I-10126 urin, Italy
Citazione:
E. Arvat et al., "Adrenocorticotropin and cortisol hyperresponsiveness to hexarelin in patients with Cushing's disease bearing a pituitary microadenoma, but not in those with macroadenoma", J CLIN END, 83(12), 1998, pp. 4207-4211

Abstract

We previously reported that in Gushing's disease (CD) the ACTH- and cortisol (F)-releasing activity of Hexarelin (HEX), a GH secretagogue, is exaggerated with respect to that in normal subjects and is higher than that of human CRH (hGRH), but it is absent in Gushing's syndrome. Our aim was to extend the study about the effects of HEX (2.0 mu g/kg, iv) on ACTH and F secretion in 21 patients with CD (3 men and 18 women, 16-68 yr old). Based on magnetic resonance imaging, 15 GD patients had pituitary microadenoma, and 6 had macroadenoma. The results in CD patients were compared with those in 27 normal age-matched controls (NS; 10 men and 17 women, 24-69 yr old). Basal ACTH and F levels in CD were similar in patients with microadenom (mean +/-SEM, 78.3 +/- 7.2 pg/mL, and 237.1 +/- 23.6 mu g/L, respectively) and macroadenoma (57.4 +/- 9.0 pg/mL and 196.4 +/- 20.1 mu g/L, respectively) and were higher (P < 0.001) than those in NS (11.7 +/- 2.0 pg/mL and 115.3 +/- 6.7 mu g/L, respectively). In microadenoma CD patients, HEX induced marked ACTH and F increases (Delta peak, mean +/- SEM: 261.2 +/- 77.6 pg/mL, and 226.1 +/- 87.2 mu g/L, respectively), which were higher (P < 0.04) than thoseinduced by hCRH (45.6 +/- 16.9 pg/mL and 84.6 +/- 25.7 mu g/L, respectively). Moreover, in microadenoma CD patients, the ACTH and F responses to HEX were higher (P < 0.001) than those in NS (18.5 +/- 4.0 pg/mL and 36.1 +/- 6.8 mu g/L, respectively). In macroadenoma CD patients, HEX induced a slight, but significant increase (P < 0.02) in ACTH and F levels (33.9 +/- 18.0 pg/mL and 89.6 +/- 54.3 mu g/L, respectively), which was not significantly different from that elicited by hCRH (20.0 +/- 7.0 pg/mL and 54.8 +/- 21.3 mu g/L, respectively). In macroadenoma CD patients, the ACTH and F responsesto HEX and hCRH were, in turn, similar to those in NS. In conclusion, our findings demonstrate that the ACTH and F hyperresponsiveness to HEX is present in Gushing's disease with micro-, but not macro- ACTH-secreting pituitary adenoma. This finding agrees with other evidence pointing toward differences in the hormonal behavior between micro- and ACTH-secreting pituitary macroadenomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:49:06